{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:22:17Z","timestamp":1790911337489,"version":"4.1.0"},"reference-count":37,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4727","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1985,11,15]]},"abstract":"<jats:p>\n            The gene encoding the circumsporozoite (CS) protein of the human malaria parasite\n            <jats:italic>Plasmodium vivax<\/jats:italic>\n            has been cloned. The deduced sequence of the protein consists of 373 amino acids with a central region of 19 tandem repeats of the nonapeptide Asp-Arg-Ala-Asp\/Ala-Gly-Gln-Pro-Ala-Gly. A synthetic 18-amino acid peptide containing two tandem repeats binds to a monoclonal antibody directed to the CS protein of\n            <jats:italic>Plasmodium vivax<\/jats:italic>\n            and inhibits the interaction of this antibody with the native protein in sporozoite extracts. The portions of the CS gene that do not contain repeats are closely related to the corresponding regions of the CS genes of two simian malarias,\n            <jats:italic>Plasmodium cynomolgi<\/jats:italic>\n            and\n            <jats:italic>Plasmodium knowlesi<\/jats:italic>\n            . In contrast, the homology between the CS genes of\n            <jats:italic>Plasmodium vivax<\/jats:italic>\n            and\n            <jats:italic>Plasmodium falciparum<\/jats:italic>\n            , another malaria parasite of humans, is very limited.\n          <\/jats:p>","DOI":"10.1126\/science.2414847","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T19:42:50Z","timestamp":1160077370000},"page":"815-818","source":"Crossref","is-referenced-by-count":194,"title":["Circumsporozoite Protein of\n            <i>Plasmodium vivax<\/i>\n            : Gene Cloning and Characterization of the Immunodominant Epitope"],"prefix":"10.1126","volume":"230","author":[{"given":"David E.","family":"Arnot","sequence":"first","affiliation":[{"name":"Department of Medical and Molecular Parasitology, New York University Medical Center, New York 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Barnwell","sequence":"additional","affiliation":[{"name":"Department of Medical and Molecular Parasitology, New York University Medical Center, New York 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Tam","sequence":"additional","affiliation":[{"name":"Rockefeller University, New York 10021"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Nussenzweig","sequence":"additional","affiliation":[{"name":"Department of Pathology, New York University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth S.","family":"Nussenzweig","sequence":"additional","affiliation":[{"name":"Department of Medical and Molecular Parasitology, New York University Medical Center, New York 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Enea","sequence":"additional","affiliation":[{"name":"Department of Medical and Molecular Parasitology, New York University Medical Center, New York 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","first-page":"6652","volume":"80","year":"1983","unstructured":"Anders, R. 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The Primate Malarias (1971)."},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0166-6851(85)90110-0","volume":"14","year":"1985","unstructured":"COCHRANE, A.H., ANTIGENIC DIVERSITY OF THE CIRCUMSPOROZOITE PROTEINS IN THE PLASMODIUM-CYNOMOLGI COMPLEX, MOLECULAR AND BIOCHEMICAL PARASITOLOGY 14: 111 (1985).","journal-title":"MOLECULAR AND BIOCHEMICAL PARASITOLOGY"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/310789a0","volume":"310","year":"1984","unstructured":"COPPEL, P.C., NATURE 310: 789 (1984).","journal-title":"NATURE"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/306751a0","volume":"306","year":"1983","unstructured":"COPPEL, R.L., ISOLATE-SPECIFIC S-ANTIGEN OF PLASMODIUM-FALCIPARUM CONTAINS A REPEATED SEQUENCE OF 11 AMINO-ACIDS, NATURE 306: 751 (1983).","journal-title":"NATURE"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/0092-8674(85)90337-X","volume":"40","year":"1985","unstructured":"COWMAN, A.F., CONSERVED SEQUENCES FLANK VARIABLE TANDEM REPEATS IN 2 S-ANTIGEN GENES OF PLASMODIUM-FALCIPARUM, CELL 40: 775 (1985).","journal-title":"CELL"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6204383"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/302536a0","volume":"302","year":"1983","unstructured":"ELLIS, J, CLONING AND EXPRESSION IN ESCHERICHIA-COLI OF THE MALARIAL SPOROZOITE SURFACE-ANTIGEN GENE FROM PLASMODIUM-KNOWLESI, NATURE 302: 536 (1983).","journal-title":"NATURE"},{"key":"e_1_2_1_11_1","first-page":"7520","volume":"81","year":"1984","unstructured":"ENEA, V, CIRCUMSPOROZOITE GENE OF PLASMOIDIUM-CYNOMOLGI (GOMBAK) - CDNA CLONING AND EXPRESSION OF THE REPETITIVE CIRCUMSPOROZOITE EPITOPE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 81: 7520 (1984).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6204384"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S0022-2836(83)80190-9","volume":"170","year":"1983","unstructured":"FRISCHAUF, A.M., LAMBDA-REPLACEMENT VECTORS CARRYING POLYLINKER SEQUENCES, JOURNAL OF MOLECULAR BIOLOGY 170: 827 (1983).","journal-title":"JOURNAL OF MOLECULAR BIOLOGY"},{"key":"e_1_2_1_14_1","unstructured":"GALINSKI M unpublished data."},{"key":"e_1_2_1_15_1","unstructured":"Garnham P. 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