{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:37:36Z","timestamp":1789727856181,"version":"4.0.1"},"reference-count":28,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4769","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1986,9,12]]},"abstract":"<jats:p>\n            The observation that voltage-dependent K\n            <jats:sup>+<\/jats:sup>\n            channels are required for activation of human T lymphocytes suggests that pathological conditions involving abnormal mitogen responses might be reflected in ion channel abnormalities. Gigaohm seal techniques were used to study T cells from MRL\/MpJ-\n            <jats:italic>lpr<\/jats:italic>\n            \/\n            <jats:italic>lpr<\/jats:italic>\n            mice; these mice develop generalized lymphoproliferation of functionally and phenotypically abnormal T cells and a disease resembling human systemic lupus erythematosus. The number and predominant type of K\n            <jats:sup>+<\/jats:sup>\n            channels in T cells from these mice differ dramatically from those in T cells from control strains and a congenic strain lacking the\n            <jats:italic>lpr<\/jats:italic>\n            gene locus. Thus an abnormal pattern of ion channel expression has now been associated with a genetic defect in cells of the immune system.\n          <\/jats:p>","DOI":"10.1126\/science.2426784","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T20:28:52Z","timestamp":1160080132000},"page":"1197-1200","source":"Crossref","is-referenced-by-count":42,"title":["Altered K\n            <sup>+<\/sup>\n            Channel Expression in Abnormal T Lymphocytes from Mice with the\n            <i>lpr<\/i>\n            Gene Mutation"],"prefix":"10.1126","volume":"233","author":[{"given":"K. George","family":"Chandy","sequence":"first","affiliation":[{"name":"Division of Basic and Clinical Immunology, Department of Medicine, University of California, Irvine, CA 92717."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"DeCoursey","sequence":"additional","affiliation":[{"name":"Department of Physiology, Rush- Presbyterian-St. Luke's Medical Center, Chicago, IL 60612."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Fischbach","sequence":"additional","affiliation":[{"name":"Department of Medicine, Audie Murphy Veterans Administration Hospital, University of Texas Health Sciences Center, San Antonio, TX 78284."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman","family":"Talal","sequence":"additional","affiliation":[{"name":"Department of Medicine, Audie Murphy Veterans Administration Hospital, University of Texas Health Sciences Center, San Antonio, TX 78284."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Cahalan","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, University of California, Irvine, CA 92717."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudhir","family":"Gupta","sequence":"additional","affiliation":[{"name":"Division of Basic and Clinical Immunology, Department of Medicine, University of California, Irvine, CA 92717."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1084\/jem.154.3.791","volume":"154","year":"1981","unstructured":"ALTMAN, A, ANALYSIS OF T-CELL FUNCTION IN AUTOIMMUNE MURINE STRAINS - 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