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A point mutation in the binding region of the PA682 c-\n            <jats:italic>myc<\/jats:italic>\n            DNA abolished binding of this nuclear protein. This protein may be an important factor for control of c-\n            <jats:italic>myc<\/jats:italic>\n            expression, and mutations in its recognition sequence may be associated with c-\n            <jats:italic>myc<\/jats:italic>\n            activation in many cases of Burkitt lymphoma.\n          <\/jats:p>","DOI":"10.1126\/science.2454510","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T21:21:15Z","timestamp":1160083275000},"page":"1776-1780","source":"Crossref","is-referenced-by-count":76,"title":["A Point Mutation in the c-\n            <i>myc<\/i>\n            Locus of a Burkitt Lymphoma Abolishes Binding of a Nuclear Protein"],"prefix":"10.1126","volume":"240","author":[{"given":"Maria","family":"Zajac-Kaye","sequence":"first","affiliation":[{"name":"Medicine Branch, Clinical Oncology Program, National Cancer Institute, Bethesda, MD 20892."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward P.","family":"Gelmann","sequence":"additional","affiliation":[{"name":"Medicine Branch, Clinical Oncology Program, National Cancer Institute, Bethesda, MD 20892."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Levens","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6414084"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/0092-8674(83)90534-2","volume":"34","year":"1983","unstructured":"BATTEY, J, THE HUMAN C-MYC-ONCOGENE - STRUCTURAL CONSEQUENCES OF TRANSLOCATION INTO THE IGH LOCUS IN BURKITT-LYMPHOMA, CELL 34: 779 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SCIENCES OF THE UNITED STATES OF AMERICA 83: 7918 (1986).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/0092-8674(87)90034-1","volume":"50","year":"1987","unstructured":"DELAPENA, P, ENHANCEMENT OF MESSENGER-RNA NUCLEAR TRANSPORT BY PROMOTER ELEMENTS, CELL 50: 613 (1987).","journal-title":"CELL"},{"key":"e_1_2_1_8_1","first-page":"3199","volume":"5","year":"1985","unstructured":"DENNY, C.T., BURKITT-LYMPHOMA CELL-LINE CARRYING A VARIANT TRANSLOCATION CREATES NEW DNA AT THE BREAKPOINT AND VIOLATES THE HIERARCHY OF IMMUNOGLOBULIN GENE REARRANGEMENT, MOLECULAR AND CELLULAR BIOLOGY 5: 3199 (1985).","journal-title":"MOLECULAR AND CELLULAR BIOLOGY"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/0076-6879(83)01039-3","volume":"101","year":"1983","unstructured":"DINGMAN, J.D., METHODS IN ENZYMOLOGY 101: 582 (1983).","journal-title":"METHODS IN ENZYMOLOGY"},{"key":"e_1_2_1_10_1","first-page":"820","volume":"80","year":"1983","unstructured":"ERIKSON, J, TRANSCRIPTIONAL ACTIVATION OF THE TRANSLOCATED C-MYC ONCOGENE IN BURKITT-LYMPHOMA, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 80: 820 (1983).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES"},{"key":"e_1_2_1_11_1","first-page":"3517","volume":"5","year":"1978","unstructured":"GALAS, D, NUCLEIC ACIDS RES 5: 3517 (1978).","journal-title":"NUCLEIC ACIDS RES"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/j.1460-2075.1984.tb01816.x","volume":"3","year":"1984","unstructured":"GAZIN, C, NUCLEOTIDE-SEQUENCE OF THE HUMAN C-MYC LOCUS - PROVOCATIVE OPEN READING FRAME WITHIN THE 1ST EXON, EMBO JOURNAL 3: 383 (1984).","journal-title":"EMBO JOURNAL"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/306799a0","volume":"306","year":"1983","unstructured":"GELMANN, E.P., IDENTIFICATION OF RECIPROCAL TRANSLOCATION SITES WITHIN THE C-MYC ONCOGENE AND IMMUNOGLOBULIN-MU LOCUS IN A BURKITT-LYMPHOMA, NATURE 306: 799 (1983).","journal-title":"NATURE"},{"key":"e_1_2_1_14_1","first-page":"787","volume":"3","year":"1983","unstructured":"GUNNING, P, ISOLATION AND CHARACTERIZATION OF FULL-LENGTH CDNA CLONES FOR HUMAN ALPHA-ACTIN, BETA-ACTIN AND GAMMA-ACTIN MESSENGER-RNAS - SKELETAL BUT NOT CYTOPLASMIC ACTINS HAVE AN AMINO-TERMINAL CYSTEINE THAT IS SUBSEQUENTLY REMOVED, MOLECULAR AND CELLULAR BIOLOGY 3: 787 (1983).","journal-title":"MOLECULAR AND CELLULAR BIOLOGY"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/304135a0","volume":"304","year":"1983","unstructured":"HAMLYN, P.H., TRANSLOCATION JOINS C-MYC AND IMMUNOGLOBULIN-GAMMA-1 GENES IN A BURKITT-LYMPHOMA 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(1984).","journal-title":"NATURE"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0092-8674(83)90410-5","volume":"33","year":"1983","unstructured":"KHOURY, G, ENHANCER ELEMENTS, CELL 33: 313 (1983).","journal-title":"CELL"},{"key":"e_1_2_1_20_1","first-page":"2307","volume":"5","year":"1985","unstructured":"LEVENS, D, NOVEL METHOD FOR IDENTIFYING SEQUENCE-SPECIFIC DNA-BINDING PROTEINS, MOLECULAR AND CELLULAR BIOLOGY 5: 2307 (1985).","journal-title":"MOLECULAR AND CELLULAR BIOLOGY"},{"key":"e_1_2_1_21_1","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1126\/science.6316501","volume":"222","year":"1983","unstructured":"MAGRATH, I, SYNTHESIS OF KAPPA-LIGHT CHAINS BY CELL-LINES CONTAINING AN 8-22 CHROMOSOMAL TRANSLOCATION DERIVED FROM A MALE-HOMOSEXUAL WITH BURKITTS-LYMPHOMA, SCIENCE 222: 1094 (1983).","journal-title":"SCIENCE"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1016\/S0021-9258(17)35944-6","volume":"261","year":"1986","unstructured":"MARTIN, M.B., DIFFERENTIAL INDUCTION OF VITELLOGENIN GENE-TRANSCRIPTION AND TOTAL TRANSCRIPTIONAL ACTIVITY BY ESTROGEN IN XENOPUS-LAEVIS LIVER, JOURNAL OF BIOLOGICAL CHEMISTRY 261: 2355 (1986).","journal-title":"JOURNAL OF BIOLOGICAL CHEMISTRY"},{"key":"e_1_2_1_23_1","first-page":"679","volume":"83","year":"1986","unstructured":"MCCARREY, J.R., DETERMINATOR-INHIBITOR PAIRS AS A MECHANISM FOR THRESHOLD SETTING IN DEVELOPMENT - A POSSIBLE FUNCTION FOR PSEUDOGENES, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 83: 679 (1986).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF 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