{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:39:20Z","timestamp":1791049160538,"version":"4.1.0"},"reference-count":16,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4865","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1988,7,29]]},"abstract":"<jats:p>\n            The ionic currents of carotid body type I cells and their possible involvement in the detection of oxygen tension (\n            <jats:italic>P<\/jats:italic>\n            O\n            <jats:sub>2<\/jats:sub>\n            ) in arterial blood are unknown. The electrical properties of these cells were studied with the whole-cell patch clamp technique, and the hypothesis that ionic conductances can be altered by changes in\n            <jats:italic>P<\/jats:italic>\n            O\n            <jats:sub>2<\/jats:sub>\n            was tested. The results show that type I cells have voltage-dependent sodium, calcium, and potassium channels. Sodium and calcium currents were unaffected by a decrease in\n            <jats:italic>P<\/jats:italic>\n            O\n            <jats:sub>2<\/jats:sub>\n            from 150 to 10 millimeters of mercury, whereas, with the same experimental protocol, potassium currents were reversibly reduced by 25 to 50 percent. The effect of hypoxia was independent of internal adenosine triphosphate and calcium. Thus, ionic conductances, and particularly the O\n            <jats:sub>2<\/jats:sub>\n            -sensitive potassium current, play a key role in the transduction mechanism of arterial chemoreceptors.\n          <\/jats:p>","DOI":"10.1126\/science.2456613","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T21:21:15Z","timestamp":1160083275000},"page":"580-582","source":"Crossref","is-referenced-by-count":467,"title":["Chemotransduction in the Carotid Body: K\n            <sup>+<\/sup>\n            Current Modulated by\n            <i>P<\/i>\n            O\n            <sub>2<\/sub>\n            In Type I Chemoreceptor Cells"],"prefix":"10.1126","volume":"241","author":[{"given":"Jos\u00e9","family":"L\u00f3pez-Barneo","sequence":"first","affiliation":[{"name":"Departmento de Fisiolog\u00eda, Facultad de Medicina, Universidad de Sevilla, 41009 Sevilla Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 R.","family":"L\u00f3pez-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular y Fisiolog\u00eda, Facultad de Medicina, Universidad de Valladolid, 47005 Valladolid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju\u00e1n","family":"Ure\u00f1a","sequence":"additional","affiliation":[{"name":"Departmento de Fisiolog\u00eda, Facultad de Medicina, Universidad de Sevilla, 41009 Sevilla Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constancio","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular y Fisiolog\u00eda, Facultad de Medicina, Universidad de Valladolid, 47005 Valladolid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1986.sp016254"},{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2437654"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/331351a0"},{"key":"e_1_2_1_4_1","first-page":"197","year":"1983","unstructured":"BELMONTE, C, PHISIOLOGY PERIPHERA: 197 (1983).","journal-title":"PHISIOLOGY PERIPHERA"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.70.5.549"},{"key":"e_1_2_1_6_1","first-page":"213","year":"1968","unstructured":"EYZAGUIRRE, C, ARTERIAL CHEMORECEPT: 213 (1968).","journal-title":"ARTERIAL CHEMORECEPT"},{"key":"e_1_2_1_7_1","first-page":"59","year":"1983","unstructured":"EYZAGUIRRE, C, PHYSL PERIPHERAL ART: 59 (1983).","journal-title":"PHYSL PERIPHERAL ART"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1982.sp014441"},{"key":"e_1_2_1_9_1","first-page":"247","volume":"2","year":"1986","unstructured":"FIDONE, S.J., HDB PHYSL RESPIRATOR 2: 247 (1986).","journal-title":"HDB PHYSL RESPIRATOR"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00656997"},{"key":"e_1_2_1_11_1","first-page":"400","volume":"39","year":"1930","unstructured":"HEYMANS, C, Carotid sinus and respiratory reflexes. II. Reflex respiratory influences of the acidosis, of the carbonic anhydride, of the hydrogen ion and of the anoxemia. Carotid sinuses and respiratory exchanges in the lungs and seaward of the lungs, ARCHIVES INTERNATIONALES DE PHARMACODYNAMIE ET DE THERAPIE 39: 400 (1930).","journal-title":"ARCHIVES INTERNATIONALES DE PHARMACODYNAMIE ET DE THERAPIE"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00210887"},{"key":"e_1_2_1_13_1","first-page":"221","year":"1983","unstructured":"LAHIRI, S, PHYSL PERIPHERAL ART: 221 (1983).","journal-title":"PHYSL PERIPHERAL ART"},{"key":"e_1_2_1_14_1","unstructured":"LOPEZBARNEO J unpublished data."},{"key":"e_1_2_1_15_1","first-page":"91","year":"1987","unstructured":"OBESO, A, CHEMORECEPTORS RESPI: 91 (1987).","journal-title":"CHEMORECEPTORS RESPI"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/331354a0"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.2456613","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T15:26:26Z","timestamp":1705073186000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.2456613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,7,29]]},"references-count":16,"journal-issue":{"issue":"4865","published-print":{"date-parts":[[1988,7,29]]}},"alternative-id":["10.1126\/science.2456613"],"URL":"https:\/\/doi.org\/10.1126\/science.2456613","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,7,29]]}}}