{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T08:51:10Z","timestamp":1770713470034,"version":"3.49.0"},"reference-count":23,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4876","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1988,10,14]]},"abstract":"<jats:p>\n            <jats:italic>Mycobacterium leprae<\/jats:italic>\n            induces T cell reactivity and protective immunity in the majority of exposed individuals, but the minority that develop leprosy exhibit various types of immunopathology. Thus, the definition of epitopes on\n            <jats:italic>M. leprae<\/jats:italic>\n            antigens that are recognized by T cells from different individuals might result in the development of an effective vaccine against leprosy. A sequence from the 65-kD protein of this organism was recognized by two HLA-DR2-restricted,\n            <jats:italic>M. leprae<\/jats:italic>\n            -specific helper T cell clones that were derived from a tuberculoid leprosy patient. Synthetic peptides were used to define this epitope as Leu-Gln-Ala-Ala-Pro-Ala-Leu-Asp-Lys-Leu. A similar peptide that was derived from the third hypervariable region of the HLA-DR2 chain, Glu-Gln-Ala-Arg-Ala-Ala-Val-Asp-Thr-Tyr, also activated the same clones. The unexpected cross-reactivity of this\n            <jats:italic>M. leprae<\/jats:italic>\n            -specific DR2-restricted T cell epitope with a DR2 peptide may have to be considered in the design of subunit vaccines against leprosy.\n          <\/jats:p>","DOI":"10.1126\/science.2459778","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T21:21:15Z","timestamp":1160083275000},"page":"259-261","source":"Crossref","is-referenced-by-count":48,"title":["A\n            <i>Mycobacterium leprae<\/i>\n            -Specific Human T Cell Epitope Cross-Reactive with an HLA-DR2 Peptide"],"prefix":"10.1126","volume":"242","author":[{"given":"D. C.","family":"Anderson","sequence":"first","affiliation":[{"name":"University of Washington, Seattle, WA 98195."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wim C.","family":"van Schooten","sequence":"additional","affiliation":[{"name":"Department of Immunohematology and Blood Bank, Univcrsity Hospital, Lciden, The Neithrlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael E.","family":"Barry","sequence":"additional","affiliation":[{"name":"University of Washington, Seattle, WA 98195."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anneke A. M.","family":"Janson","sequence":"additional","affiliation":[{"name":"Department of Immunohematology and Blood Bank, Univcrsity Hospital, Lciden, The Neithrlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom M.","family":"Buchanan","sequence":"additional","affiliation":[{"name":"University of Washington, Seattle, WA 98195."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9 R. P.","family":"de Vries","sequence":"additional","affiliation":[{"name":"Department of Immunohematology and Blood Bank, Univcrsity Hospital, Lciden, The Neithrlands."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"607","DOI":"10.4049\/jimmunol.141.2.607","volume":"141","year":"1988","unstructured":"ANDERSON, D.C., EXACT DEFINITION OF SPECIES-SPECIFIC AND CROSS-REACTIVE EPITOPES OF THE 65-KILODALTON PROTEIN OF MYCOBACTERIUM-LEPRAE USING SYNTHETIC PEPTIDES, JOURNAL OF IMMUNOLOGY 141: 607 (1988).","journal-title":"JOURNAL OF IMMUNOLOGY"},{"key":"e_1_2_1_2_1","first-page":"1","year":"1980","unstructured":"Barany, G., The Peptides, Analysis, Synthesis, Biology: 1 (1980).","journal-title":"The Peptides, Analysis, Synthesis, Biology"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.4049\/jimmunol.137.1.1","volume":"137","year":"1986","unstructured":"BLOOM, B.R., LEARNING FROM LEPROSY - A PERSPECTIVE ON IMMUNOLOGY AND THE THIRD-WORLD, JOURNAL OF IMMUNOLOGY 137: R1 (1986).","journal-title":"JOURNAL OF IMMUNOLOGY"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1128\/iai.55.4.1000-1003.1987","volume":"55","year":"1987","unstructured":"BUCHANAN, T.M., CHARACTERIZATION OF ANTIBODY-REACTIVE EPITOPES ON THE 65-KILODALTON PROTEIN OF MYCOBACTERIUM-LEPRAE, INFECTION AND IMMUNITY 55: 1000 (1987).","journal-title":"INFECTION AND IMMUNITY"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2435001"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1084\/jem.164.5.1440","volume":"164","year":"1986","unstructured":"CEASE, K.B., IMMUNOLOGICALLY RELEVANT PEPTIDE ANTIGEN EXISTS ON THE PRESENTING CELL IN A MANNER ACCESSIBLE TO MACROMOLECULES IN SOLUTION, JOURNAL OF EXPERIMENTAL MEDICINE 164: 1440 (1986).","journal-title":"JOURNAL OF EXPERIMENTAL MEDICINE"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/308547a0","volume":"308","year":"1984","unstructured":"CORRADIN, G, INHIBITION OF ANTIGEN-INDUCED T-CELL CLONE PROLIFERATION BY ANTIGEN-SPECIFIC ANTIBODIES, NATURE 308: 547 (1984).","journal-title":"NATURE"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0167-5699(87)90843-7","volume":"8","year":"1987","unstructured":"CRESSWELL, P, ANTIGEN RECOGNITION BY LYMPHOCYTES-T, IMMUNOLOGY TODAY 8: 67 (1987).","journal-title":"IMMUNOLOGY TODAY"},{"key":"e_1_2_1_9_1","first-page":"113","volume":"57","year":"1986","unstructured":"DE VRIES, R. 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