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These results suggest that this defective virus is oncogenic, inducing a primary neoplasia associated with an acquired immunodeficiency syndrome as a paraneoplastic syndrome. These data emphasize the need to determine whether virus replication is necessary for the progression of other immunodeficiency diseases, including acquired immunodeficiency syndrome, and whether these diseases also represent paraneoplastic syndromes.<\/jats:p>","DOI":"10.1126\/science.2480643","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T21:21:28Z","timestamp":1160083288000},"page":"1614-1617","source":"Crossref","is-referenced-by-count":87,"title":["Immunodeficiency and Clonal Growth of Target Cells Induced by Helper-Free Defective Retrovirus"],"prefix":"10.1126","volume":"246","author":[{"given":"Ming","family":"Huang","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Biology, Clinical Research Institute of Montreal, Quebec, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carole","family":"Simard","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, Clinical Research Institute of Montreal, Quebec, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Jolicoeur","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, Clinical Research Institute of Montreal, Quebec, Canada."},{"name":"Department of Microbiology and Immunology, University of Montreal, Montreal, Quebec, Canada, H3C 3J7."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/338505a0","volume":"338","year":"1989","unstructured":"AZIZ, D.C., SEVERE IMMUNODEFICIENCY DISEASE INDUCED BY A DEFECTIVE MURINE LEUKEMIA-VIRUS, NATURE 338: 505 (1989).","journal-title":"NATURE"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1128\/jvi.61.2.383-387.1987","volume":"61","year":"1987","unstructured":"BULLER, RML, ABROGATION OF RESISTANCE TO SEVERE MOUSEPOX IN C57BL\/6 MICE INFECTED WITH LP-BM5 MURINE LEUKEMIA VIRUSES, JOURNAL OF VIROLOGY 61: 383 (1987).","journal-title":"JOURNAL OF VIROLOGY"},{"key":"e_1_2_1_3_1","first-page":"5774","volume":"77","year":"1980","unstructured":"Chattopadhyay, S. 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