{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:59:58Z","timestamp":1791086398028,"version":"4.1.0"},"reference-count":24,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4900","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1989,4,7]]},"abstract":"<jats:p>\n            Three cellular homologs of the v-\n            <jats:italic>erbA<\/jats:italic>\n            oncogene were previously identified in the rat; two of them encode high affinity receptors for the thyroid hormone triiodothyronine (T\n            <jats:sub>3<\/jats:sub>\n            ). A rat complementary DNA clone encoding a T\n            <jats:sub>3<\/jats:sub>\n            receptor form of the ErbA protein, called r-ErbA\u03b2-2, was isolated. The r-ErbA\u03b2-2 protein differs at its amino terminus from the previously described rat protein encoded by c-\n            <jats:italic>erbA<\/jats:italic>\n            \u03b2 and referred to as r-ErbA\u03b2-1. Unlike the other members of the c-\n            <jats:italic>erbA<\/jats:italic>\n            proto-oncogene family, which have a wide tissue distribution, r-\n            <jats:italic>erbA<\/jats:italic>\n            \u03b2-2 appears to be expressed only in the anterior pituitary gland. In addition, thyroid hormone downregulates r-\n            <jats:italic>erbA<\/jats:italic>\n            \u03b2-2 messenger RNA but not r-\n            <jats:italic>erbA<\/jats:italic>\n            \u03b2-1 messenger RNA in a pituitary tumor-derived cell line. The presence of a pituitary-specific form of the thyroid hormone receptor that may be selectively regulated by thyroid hormone could be important for the differential regulation of gene expression by T\n            <jats:sub>3<\/jats:sub>\n            in the pituitary gland.\n          <\/jats:p>","DOI":"10.1126\/science.2539642","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T21:21:28Z","timestamp":1160083288000},"page":"76-79","source":"Crossref","is-referenced-by-count":330,"title":["Identification of a tHyroid Hormone Receptor That Is Pituitary-Specific"],"prefix":"10.1126","volume":"244","author":[{"given":"Richard A.","family":"Hodin","sequence":"first","affiliation":[{"name":"Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell A.","family":"Lazar","sequence":"additional","affiliation":[{"name":"Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce I.","family":"Wintman","sequence":"additional","affiliation":[{"name":"Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas S.","family":"Darling","sequence":"additional","affiliation":[{"name":"Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald J.","family":"Koenig","sequence":"additional","affiliation":[{"name":"Thyroid Division, Brigham and Women's Hospital, Boston, MA 02115."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Reed","family":"Larsen","sequence":"additional","affiliation":[{"name":"Thyroid Division, Brigham and Women's Hospital, Boston, MA 02115."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David D.","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Wellman 9, Massachusetts General Hospital, Boston, MA 02114."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William W.","family":"Chin","sequence":"additional","affiliation":[{"name":"Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/0039-128X(75)90073-2","volume":"26","year":"1975","unstructured":"CHAMNESS, G.C., SCATCHARD PLOTS - COMMON ERRORS IN CORRECTION AND INTERPRETATION, STEROIDS 26: 538 (1975).","journal-title":"STEROIDS"},{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00591a005"},{"key":"e_1_2_1_3_1","unstructured":"HODIN R.A. unpublished data."},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0092-8674(87)90753-7","volume":"49","year":"1987","unstructured":"HOLLENBERG, S.M., COLOCALIZATION OF DNA-BINDING AND TRANSCRIPTIONAL ACTIVATION FUNCTIONS IN THE HUMAN GLUCOCORTICOID RECEPTOR, CELL 49: 39 (1987).","journal-title":"CELL"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/334539a0","volume":"334","year":"1988","unstructured":"IZUMO, S, THYROID-HORMONE RECEPTOR-ALPHA ISOFORMS GENERATED BY ALTERNATIVE SPLICING DIFFERENTIALLY ACTIVATE MYOSIN HC GENE-TRANSCRIPTION, NATURE 334: 539 (1988).","journal-title":"NATURE"},{"key":"e_1_2_1_6_1","first-page":"5031","volume":"85","year":"1988","unstructured":"KOENIG, R.J., ISOLATION OF A CDNA CLONE ENCODING A BIOLOGICALLY-ACTIVE THYROID-HORMONE RECEPTOR, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 85: 5031 (1988).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1210\/mend-2-6-479","volume":"2","year":"1988","unstructured":"LAZAR, M.A., REGULATION OF 2 C-ERBA MESSENGER RIBONUCLEIC-ACIDS IN RAT GH3 CELLS BY THYROID-HORMONE, MOLECULAR ENDOCRINOLOGY 2: 479 (1988).","journal-title":"MOLECULAR ENDOCRINOLOGY"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1210\/mend-2-10-893","volume":"2","year":"1988","unstructured":"LAZAR, M.A., IDENTIFICATION OF A RAT C-ERBA-ALPHA- RELATED PROTEIN WHICH BINDS DEOXYRIBONUCLEIC-ACID BUT DOES NOT BIND THYROID-HORMONE, MOLECULAR ENDOCRINOLOGY 2: 893 (1988).","journal-title":"MOLECULAR ENDOCRINOLOGY"},{"key":"e_1_2_1_9_1","unstructured":"LAZAR M.A. unpublished data."},{"key":"e_1_2_1_10_1","unstructured":"Maniatis T. 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