{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:11:21Z","timestamp":1790313081504,"version":"4.1.0"},"reference-count":30,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4887","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1989,1,6]]},"abstract":"<jats:p>\n            The\n            <jats:italic>ZFY<\/jats:italic>\n            gene in the sex-determining region of the human Y chromosome encodes a \"zinc-finger\" protein that may be the testis-determining factor,\n            <jats:italic>TDF<\/jats:italic>\n            . Although the Y chromosomes of most placental mammals carry a single homolog of\n            <jats:italic>ZFY<\/jats:italic>\n            , the mouse Y chromosome has two homologs, both in the sex-determining (\n            <jats:italic>Sxr<\/jats:italic>\n            ) region.\n            <jats:italic>Zfy-1<\/jats:italic>\n            alone may suffice to determine maleness;\n            <jats:italic>Zfy-2<\/jats:italic>\n            is dispensable, as it was deleted in an\n            <jats:italic>Sxr<\/jats:italic>\n            variant that retains sex-determining function but has lost other genes. Both loci mapped near the centromere of the mouse Y chromosome. The Y chromosomes of the subspecies\n            <jats:italic>Mus musculus musculus<\/jats:italic>\n            and\n            <jats:italic>M. m. domesticus<\/jats:italic>\n            were distinguishable by a\n            <jats:italic>Zfy-1<\/jats:italic>\n            restriction fragment polymorphism, which can be used to study their differing interactions with autosomal sex-determining genes.\n          <\/jats:p>","DOI":"10.1126\/science.2563173","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T21:21:28Z","timestamp":1160083288000},"page":"78-80","source":"Crossref","is-referenced-by-count":71,"title":["Duplication, Deletion, and Polymorphism in the Sex-Determining Region of the Mouse Y Chromosome"],"prefix":"10.1126","volume":"243","author":[{"given":"Graeme","family":"Mardon","sequence":"first","affiliation":[{"name":"Whitehead Institute, Nine Cambridge Center, Cambridge, MA 02142, and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Mosher","sequence":"additional","affiliation":[{"name":"Whitehead Institute, Nine Cambridge Center, Cambridge, MA 02142, and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine M","family":"Disteche","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Wash4on, Seattle, WA 98195."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Nishioka","sequence":"additional","affiliation":[{"name":"Department of Biology, McGill University, Montreal, Quebec, Canada 13A 1B1."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"McLaren","sequence":"additional","affiliation":[{"name":"MRC Mammalian Development Unit, Wolfson House, University College London, London, United Kingdom NW1 2HE."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Page","sequence":"additional","affiliation":[{"name":"Whitehead Institute, Nine Cambridge Center, Cambridge, MA 02142, and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/265255a0","volume":"265","year":"1977","unstructured":"BENNETT, D, SEROLOGICAL EVIDENCE FOR H-Y ANTIGEN IN SXR, XX SEX-REVERSED PHENOTYPIC MALES, NATURE 265: 255 (1977).","journal-title":"NATURE"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/315070a0","volume":"315","year":"1985","unstructured":"BISHOP, C.E., MOST CLASSICAL MUS-MUSCULUS-DOMESTICUS LABORATORY MOUSE STRAINS CARRY A MUS-MUSCULUS-MUSCULUS Y-CHROMOSOME, NATURE 315: 70 (1985).","journal-title":"NATURE"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(85)80723-7"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/320170a0","volume":"320","year":"1986","unstructured":"BURGOYNE, P.S., SPERMATOGENIC FAILURE IN MALE-MICE LACKING H-Y-ANTIGEN, NATURE 320: 170 (1986).","journal-title":"NATURE"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1159\/000130151","volume":"10","year":"1971","unstructured":"CATTANACH, B.M., SEX-REVERSED MICE - 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