{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T20:12:21Z","timestamp":1791058341868,"version":"4.1.0"},"reference-count":22,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4935","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1989,12,8]]},"abstract":"<jats:p>\n            The fragile X syndrome is the most common cause of familial mental retardation. Genetic counseling and gene isolation are hampered by a lack of DNA markers close to the disease locus. Two somatic cell hybrids that each contain a human X chromosome with a breakpoint close to the fragile X locus have been characterized. A new DNA marker (\n            <jats:italic>DXS296<\/jats:italic>\n            ) lies between the chromosome breakpoints and is the closest marker to the fragile X locus yet reported. The Hunter syndrome gene, which causes iduronate sulfatase deficiency, is located at the X chromosome breakpoint that is distal to this new marker, thus localizing the Hunter gene distal to the fragile X locus.\n          <\/jats:p>","DOI":"10.1126\/science.2573953","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T21:21:28Z","timestamp":1160083288000},"page":"1298-1300","source":"Crossref","is-referenced-by-count":42,"title":["A New DNA Marker Tightly Linked to the Fragile X Locus (\n            <i>FRAXA<\/i>\n            )"],"prefix":"10.1126","volume":"246","author":[{"given":"G. K.","family":"Suthers","sequence":"first","affiliation":[{"name":"Department of Histopathology, The Adelaide Children's Hospital, North Adelaide SA 5006, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. F.","family":"Callen","sequence":"additional","affiliation":[{"name":"Department of Histopathology, The Adelaide Children's Hospital, North Adelaide SA 5006, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. J.","family":"Hyland","sequence":"additional","affiliation":[{"name":"Department of Histopathology, The Adelaide Children's Hospital, North Adelaide SA 5006, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. M.","family":"Kozman","sequence":"additional","affiliation":[{"name":"Department of Histopathology, The Adelaide Children's Hospital, North Adelaide SA 5006, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Histopathology, The Adelaide Children's Hospital, North Adelaide SA 5006, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Eyre","sequence":"additional","affiliation":[{"name":"Department of Histopathology, The Adelaide Children's Hospital, North Adelaide SA 5006, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. S.","family":"Harper","sequence":"additional","affiliation":[{"name":"Institute of Medical Genetics, University Hospital of Wales, Cardiff, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. H.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Institute of Medical Genetics, University Hospital of Wales, Cardiff, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. C.","family":"Hors-Cayla","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherches de G\u00e9n\u00e9tique M\u00e9dicale, H\u00f4pital des Enfants Malades, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. E.","family":"Davies","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. V.","family":"Bell","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. R.","family":"Sutherland","sequence":"additional","affiliation":[{"name":"Department of Histopathology, The Adelaide Children's Hospital, North Adelaide SA 5006, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","unstructured":"Berger S. L. 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