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A translocated and mutated allele of c-\n            <jats:italic>myc<\/jats:italic>\n            was stably transfected into fibroblasts. The rearranged allele was expressed indistinguishably from a normal c-\n            <jats:italic>myc<\/jats:italic>\n            gene: it had serum-regulated expression, was transcribed with normal promoter preference, and was strongly attenuated. Thus mutations by themselves are insufficient to deregulate c-\n            <jats:italic>myc<\/jats:italic>\n            transcription.\n          <\/jats:p>","DOI":"10.1126\/science.2683072","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T21:21:28Z","timestamp":1160083288000},"page":"494-497","source":"Crossref","is-referenced-by-count":11,"title":["Normal Expression of a Rearranged and Mutated c-\n            <i>myc<\/i>\n            Oncogene After Transfection into Fibroblasts"],"prefix":"10.1126","volume":"246","author":[{"given":"Adam","family":"Richman","sequence":"first","affiliation":[{"name":"Biology Department, Yale University, New Haven, CT 06511."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Hayday","sequence":"additional","affiliation":[{"name":"Biology Department, Yale University, New Haven, CT 06511."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/318533a0","volume":"318","year":"1985","unstructured":"ADAMS, J.M., THE C-MYC ONCOGENE DRIVEN BY IMMUNOGLOBULIN ENHANCERS INDUCES LYMPHOID MALIGNANCY IN TRANSGENIC MICE, NATURE 318: 533 (1985).","journal-title":"NATURE"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/0092-8674(83)90534-2","volume":"34","year":"1983","unstructured":"BATTEY, J, THE HUMAN C-MYC-ONCOGENE - STRUCTURAL CONSEQUENCES OF TRANSLOCATION INTO THE IGH LOCUS IN BURKITT-LYMPHOMA, CELL 34: 779 (1983).","journal-title":"CELL"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0092-8674(88)90386-8","volume":"53","year":"1988","unstructured":"BENTLEY, D.L., SEQUENCE REQUIREMENTS FOR PREMATURE TERMINATION OF TRANSCRIPTION IN THE HUMAN C-MYC GENE, CELL 53: 245 (1988).","journal-title":"CELL"},{"key":"e_1_2_1_4_1","first-page":"3481","volume":"6","year":"1986","unstructured":"BENTLEY, D.L., NOVEL PROMOTER UPSTREAM OF THE HUMAN C-MYC GENE AND REGULATION OF C-MYC EXPRESSION IN B-CELL LYMPHOMAS, MOLECULAR AND CELLULAR BIOLOGY 6: 3481 (1986).","journal-title":"MOLECULAR AND CELLULAR BIOLOGY"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/321702a0","volume":"321","year":"1986","unstructured":"BENTLEY, D.L., A BLOCK TO ELONGATION IS LARGELY RESPONSIBLE FOR DECREASED TRANSCRIPTION OF C-MYC IN DIFFERENTIATED HL60 CELLS, NATURE 321: 702 (1986).","journal-title":"NATURE"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0092-8674(85)90029-7","volume":"43","year":"1985","unstructured":"CAUGHLIN, S.R., CELL 43: 243 (1985).","journal-title":"CELL"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3685977"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00591a005"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0065-230X(08)60200-6","volume":"47","year":"1986","unstructured":"CORY, S, ACTIVATION OF CELLULAR ONCOGENES IN HEMATOPOIETIC-CELLS BY CHROMOSOME-TRANSLOCATION, ADVANCES IN CANCER RESEARCH 47: 189 (1986).","journal-title":"ADVANCES IN CANCER RESEARCH"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6401867"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1093\/nar\/13.5.1431","volume":"13","year":"1985","unstructured":"FORT, P, VARIOUS RAT ADULT TISSUES EXPRESS ONLY ONE MAJOR MESSENGER-RNA SPECIES FROM THE GLYCERALDEHYDE-3-PHOSPHATE-DEHYDROGENASE MULTIGENIC FAMILY, NUCLEIC ACIDS RESEARCH 13: 1431 (1985).","journal-title":"NUCLEIC ACIDS RESEARCH"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/311433a0"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0092-8674(88)90507-7","volume":"52","year":"1988","unstructured":"HANN, S.R., A NON-AUG TRANSLATIONAL INITIATION IN C-MYC EXON-1 GENERATES AN N-TERMINALLY DISTINCT PROTEIN WHOSE SYNTHESIS IS DISRUPTED IN BURKITTS LYMPHOMAS, CELL 52: 185 (1988).","journal-title":"CELL"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/307334a0","volume":"307","year":"1984","unstructured":"HAYDAY, A.C., ACTIVATION OF A TRANSLOCATED HUMAN C-MYC GENE BY AN ENHANCER IN THE IMMUNOGLOBULIN HEAVY-CHAIN LOCUS, NATURE 307: 334 (1984).","journal-title":"NATURE"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/307752a0","volume":"307","year":"1984","unstructured":"Hollis, G. 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