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Low-frequency electrical pulses delivered to mouse sensory neurons in culture (0.1 hertz for 5 days) down-regulated expression of L1 messenger RNA and protein (but not NCAM). Fasciculation of neurites, adhesion of neuroblastoma cells, and the number of Schwann cells on neurites was reduced after 0.1-hertz stimulation, but higher frequencies or stimulation after synaptogenesis were without effect.<\/jats:p>","DOI":"10.1126\/science.270.5240.1369","type":"journal-article","created":{"date-parts":[[2006,10,27]],"date-time":"2006-10-27T18:19:42Z","timestamp":1161973182000},"page":"1369-1372","source":"Crossref","is-referenced-by-count":137,"title":["Regulated Expression of the Neural Cell Adhesion Molecule L1 by Specific Patterns of Neural Impulses"],"prefix":"10.1126","volume":"270","author":[{"given":"Kouichi","family":"Itoh","sequence":"first","affiliation":[{"name":"K. Itoh, B. Stevens, R. D. 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