{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T13:04:31Z","timestamp":1791551071502,"version":"4.3.4"},"reference-count":50,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5243","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1995,12,15]]},"abstract":"<jats:p>\n            Evidence suggests that CD8\n            <jats:sup>+<\/jats:sup>\n            T lymphocytes are involved in the control of human immunodeficiency virus (HIV) infection in vivo, either by cytolytic mechanisms or by the release of HIV-suppressive factors (HIV-SF). The chemokines RANTES, MIP-1\u03b1, and MIP-1\u03b2 were identified as the major HIV-SF produced by CD8\n            <jats:sup>+<\/jats:sup>\n            T cells. Two active proteins purified from the culture supernatant of an immortalized CD8\n            <jats:sup>+<\/jats:sup>\n            T cell clone revealed sequence identity with human RANTES and MIP-1\u03b1. RANTES, MIP-1\u03b1, and MIP-1\u03b2 were released by both immortalized and primary CD8\n            <jats:sup>+<\/jats:sup>\n            T cells. HIV-SF activity produced by these cells was completely blocked by a combination of neutralizing antibodies against RANTES, MIP-1\u03b1, and MIP-1\u03b2. Recombinant human RANTES, MIP-1\u03b1, and MIP-1\u03b2 induced a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). These data may have relevance for the prevention and therapy of AIDS.\n          <\/jats:p>","DOI":"10.1126\/science.270.5243.1811","type":"journal-article","created":{"date-parts":[[2006,10,27]],"date-time":"2006-10-27T18:19:42Z","timestamp":1161973182000},"page":"1811-1815","source":"Crossref","is-referenced-by-count":2348,"title":["Identification of RANTES, MIP-1\u03b1, and MIP-1\u03b2 as the Major HIV-Suppressive Factors Produced by CD8\n            <sup>+<\/sup>\n            T Cells"],"prefix":"10.1126","volume":"270","author":[{"given":"Fiorenza","family":"Cocchi","sequence":"first","affiliation":[{"name":"F. Cocchi, A. Garzino-Demo, S. K. Arya, R. C. Gallo, P. Lusso, Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony L.","family":"DeVico","sequence":"additional","affiliation":[{"name":"A. L. DeVico, Advanced BioScience Laboratories, Kensington, MD 20852, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Garzino-Demo","sequence":"additional","affiliation":[{"name":"F. Cocchi, A. Garzino-Demo, S. K. Arya, R. C. Gallo, P. Lusso, Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh K.","family":"Arya","sequence":"additional","affiliation":[{"name":"F. Cocchi, A. Garzino-Demo, S. K. Arya, R. C. Gallo, P. Lusso, Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Gallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Lusso","sequence":"additional","affiliation":[{"name":"F. Cocchi, A. Garzino-Demo, S. K. Arya, R. C. Gallo, P. 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