{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T19:08:24Z","timestamp":1777057704970,"version":"3.51.4"},"reference-count":19,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5246","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1996,1,12]]},"abstract":"<jats:p>\n            All cases of familial Alzheimer's disease are caused by mutations in either the gene for beta-amyloid precursor protein or the protein S182\/STM. The normal functions of these transmembrane proteins are unknown, and it is unclear how they relate to one another. N. N. Dewji and S. J. Singer propose that these two proteins interact in a way analogous to the Sevenless and Bride of Sevenless proteins in the developing\n            <jats:italic>Drosophila<\/jats:italic>\n            eye and the lin-12 and sel-12 proteins in the developing vulva of\n            <jats:italic>Caenorhabditis elegans<\/jats:italic>\n            . He suggests that excess deposition of amyloid, a hallmark and likely cause of Alzheimer's disease, would be a result of the abnormal processing of the protein-protein complex.\n          <\/jats:p>\n          <jats:p>This proposal is likely to provoke responses from the community. If you have a question or would like to comment on the ideas presented by Drs. Dewji and Singer in this Perspective or if you would like to read the comments posted by others, please go to our interactive Forum (click on the Forum button below). You can also read the full text of this Perspective by clicking on the Full Text button below.<\/jats:p>","DOI":"10.1126\/science.271.5246.159","type":"journal-article","created":{"date-parts":[[2006,10,27]],"date-time":"2006-10-27T18:30:41Z","timestamp":1161973841000},"page":"159-159","source":"Crossref","is-referenced-by-count":33,"title":["Genetic Clues to Alzheimer's Disease"],"prefix":"10.1126","volume":"271","author":[{"given":"Nazneen N.","family":"Dewji","sequence":"first","affiliation":[{"name":"The authors are in the Department of Biology, University of California, San Diego, La Jolla, CA 92093, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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