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Furthermore, this rejection resulted in immunity to a secondary exposure to tumor cells. These results suggest that blockade of the inhibitory effects of CTLA-4 can allow for, and potentiate, effective immune responses against tumor cells.<\/jats:p>","DOI":"10.1126\/science.271.5256.1734","type":"journal-article","created":{"date-parts":[[2006,10,27]],"date-time":"2006-10-27T14:30:41Z","timestamp":1161959441000},"page":"1734-1736","source":"Crossref","is-referenced-by-count":3462,"title":["Enhancement of Antitumor Immunity by CTLA-4 Blockade"],"prefix":"10.1126","volume":"271","author":[{"given":"Dana R.","family":"Leach","sequence":"first","affiliation":[{"name":"Cancer Research Laboratory and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew F.","family":"Krummel","sequence":"additional","affiliation":[{"name":"Cancer Research Laboratory and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Allison","sequence":"additional","affiliation":[{"name":"Cancer Research Laboratory and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/0952-7915(94)90120-1","article-title":"CD28-B7 INTERACTIONS IN T-CELL ACTIVATION","volume":"6","author":"ALLISON P. 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