{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T17:18:07Z","timestamp":1773681487996,"version":"3.50.1"},"reference-count":21,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4905","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1989,5,12]]},"abstract":"<jats:p>\n            Methotrexate coupled to maleylated bovine serum albumin was taken up efficiently through the \"scavenger\" receptors present on macrophages and led to selective killing of intracellular\n            <jats:italic>Leishmania mexicana amazonensis<\/jats:italic>\n            amastigotes in cultured hamster peritoneal macrophages. The drug conjugate was nearly 100 times as effective as free methotrexate in eliminating the intracellular parasites. Furthermore, in a model of experimental cutaneous leishmaniasis in hamsters, the drug conjugate brought about more than 90% reduction in the size of footpad lesions within 11 days. In contrast, the free drug at a similar concentration did not significantly affect lesion size. These studies demonstrate the potential of receptor-mediated drug delivery in the therapy of macrophage-associated diseases.\n          <\/jats:p>","DOI":"10.1126\/science.2717947","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T21:21:28Z","timestamp":1160083288000},"page":"705-707","source":"Crossref","is-referenced-by-count":42,"title":["Receptor-Mediated Drug Delivery to Macrophages in Chemotherapy of Leishmaniasis"],"prefix":"10.1126","volume":"244","author":[{"given":"Amitabha","family":"Mukhopadhyay","sequence":"first","affiliation":[{"name":"Institute of Microbial Technology, Chandigarh- 160 031, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gautam","family":"Chaudhuri","sequence":"additional","affiliation":[{"name":"Institute of Microbial Technology, Chandigarh- 160 031, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunil K.","family":"Arora","sequence":"additional","affiliation":[{"name":"Post Graduate Institute of Medical Education and Research, Chandigarh-160 012, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shobha","family":"Sehgal","sequence":"additional","affiliation":[{"name":"Post Graduate Institute of Medical Education and Research, Chandigarh-160 012, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandip K.","family":"Basu","sequence":"additional","affiliation":[{"name":"Institute of Microbial Technology, Chandigarh- 160 031, India."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/0024-3205(78)90270-9","volume":"22","year":"1978","unstructured":"ALVING, C.R., IMPROVED THERAPY OF EXPERIMENTAL LEISHMANIASIS BY USE OF A LIPOSOME-ENCAPSULATED ANTIMONIAL DRUG, LIFE SCIENCES 22: 1021 (1978).","journal-title":"LIFE SCIENCES"},{"key":"e_1_2_1_2_1","first-page":"55","volume":"2","year":"1984","unstructured":"Alving, C. 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