{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:47:09Z","timestamp":1791942429896,"version":"4.3.4"},"reference-count":28,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5273","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1996,7,19]]},"abstract":"<jats:p>\n            <jats:italic>Yersinia pestis<\/jats:italic>\n            , the cause of bubonic plague, is transmitted by the bites of infected fleas. Biological transmission of plague depends on blockage of the foregut of the flea by a mass of plague bacilli. Blockage was found to be dependent on the hemin storage (\n            <jats:italic>hms<\/jats:italic>\n            ) locus.\n            <jats:italic>Yersinia pestis hms<\/jats:italic>\n            mutants established long-term infection of the flea's midgut but failed to colonize the proventriculus, the site in the foregut where blockage normally develops. Thus, the\n            <jats:italic>hms<\/jats:italic>\n            locus markedly alters the course of\n            <jats:italic>Y. pestis<\/jats:italic>\n            infection in its insect vector, leading to a change in blood-feeding behavior and to efficient transmission of plague.\n          <\/jats:p>","DOI":"10.1126\/science.273.5273.367","type":"journal-article","created":{"date-parts":[[2006,10,27]],"date-time":"2006-10-27T18:30:41Z","timestamp":1161973841000},"page":"367-370","source":"Crossref","is-referenced-by-count":297,"title":["Role of the\n            <b>\n              <i>Yersinia pestis<\/i>\n            <\/b>\n            Hemin Storage (\n            <b>\n              <i>hms<\/i>\n            <\/b>\n            ) Locus in the Transmission of Plague by Fleas"],"prefix":"10.1126","volume":"273","author":[{"given":"B. Joseph","family":"Hinnebusch","sequence":"first","affiliation":[{"name":"B. J. Hinnebusch and T. G. Schwan, Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Perry","sequence":"additional","affiliation":[{"name":"R. D. Perry, Department of Microbiology and Immunology, University of Kentucky, Lexington, KY 40536-0084, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom G.","family":"Schwan","sequence":"additional","affiliation":[{"name":"B. J. Hinnebusch and T. G. Schwan, Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_2_2","first-page":"774","volume":"4","author":"BACOT A.W.","year":"1915","unstructured":"BACOT A.W., J HYG PLAGUE CAMB S3 4, 774 (1915).","journal-title":"J HYG PLAGUE CAMB S3"},{"key":"e_1_2_1_3_2","first-page":"423","volume":"3","author":"BACOT A.W.","year":"1914","unstructured":"BACOT A.W., J HYGIENE PLAGUE S 3, 423 (1914).","journal-title":"J HYGIENE PLAGUE S"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev.en.22.010177.000323","article-title":"CONTEMPORARY VIEWS ON INTERRELATIONSHIPS BETWEEN FLEAS AND PATHOGENS OF HUMAN AND ANIMAL DISEASES","volume":"22","author":"BIBIKOVA V.A.","year":"1977","unstructured":"BIBIKOVA V.A., CONTEMPORARY VIEWS ON INTERRELATIONSHIPS BETWEEN FLEAS AND PATHOGENS OF HUMAN AND ANIMAL DISEASES, ANNUAL REVIEW OF ENTOMOLOGY 22, 23 (1977).","journal-title":"ANNUAL REVIEW OF ENTOMOLOGY"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"6275","DOI":"10.1073\/pnas.90.13.6275","article-title":"ROLE OF THE INTEGUMENT IN INSECT IMMUNITY - 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