{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:07:42Z","timestamp":1760645262388},"reference-count":8,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5275","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1996,8,2]]},"abstract":"<jats:p>\n            In a paper in this week's issue, Maldonado\n            <jats:italic>et al<\/jats:italic>\n            . (\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"657\" related-article-type=\"in-this-issue\" vol=\"273\" xlink:href=\"10.1126\/science.273.5275.657\" xlink:type=\"simple\">p. 657<\/jats:related-article>\n            ) report that mice lacking most of their normal complement of the transcription factor CREB exhibit attenuation of withdrawal symptoms, implicating this transcription factor in mediation of withdrawal effects. Hyman discusses these results in the context of the other biochemical changes that occur in the neurons of the locus ceruleus, a key brain area for withdrawal.\n          <\/jats:p>","DOI":"10.1126\/science.273.5275.611","type":"journal-article","created":{"date-parts":[[2006,10,27]],"date-time":"2006-10-27T18:30:41Z","timestamp":1161973841000},"page":"611-612","source":"Crossref","is-referenced-by-count":28,"title":["Shaking Out the Cause of Addiction"],"prefix":"10.1126","volume":"273","author":[{"given":"Steven E.","family":"Hyman","sequence":"first","affiliation":[{"name":"The author is director of the National Institute of Mental Health, 5600 Fishers Lane, Rockville, MD 20857, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0092-8674(94)90400-6","article-title":"DEFICIENT LONG-TERM-MEMORY IN MICE WITH A TARGETED MUTATION OF THE CAMP-RESPONSIVE ELEMENT-BINDING PROTEIN","volume":"79","author":"BOURTCHULADZE R","year":"1994","unstructured":"BOURTCHULADZE R, DEFICIENT LONG-TERM-MEMORY IN MICE WITH A TARGETED MUTATION OF THE CAMP-RESPONSIVE ELEMENT-BINDING PROTEIN, CELL 79, 59 (1994).","journal-title":"CELL"},{"key":"e_1_2_1_3_2","first-page":"5","volume":"16","author":"CAREW T.J.","year":"1996","unstructured":"CAREW T.J., J PHARMACOL EXP THER 16, 5 (1996).","journal-title":"J PHARMACOL EXP THER"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/0896-6273(95)90225-2","article-title":"NEURONAL ADAPTATION TO AMPHETAMINE AND DOPAMINE - MOLECULAR MECHANISMS OF PRODYNORPHIN GENE-REGULATION IN RAT STRIATUM","volume":"14","author":"COLE R.L.","year":"1995","unstructured":"COLE R.L., NEURONAL ADAPTATION TO AMPHETAMINE AND DOPAMINE - MOLECULAR MECHANISMS OF PRODYNORPHIN GENE-REGULATION IN RAT STRIATUM, NEURON 14, 813 (1995).","journal-title":"NEURON"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0896-6273(00)80109-9","article-title":"Drug addiction: The Yin and Yang of hedonic homeostasis","volume":"16","author":"KOOB G.F.","year":"1996","unstructured":"KOOB G.F., Drug addiction: The Yin and Yang of hedonic homeostasis, NEURON 16, 893 (1996).","journal-title":"NEURON"},{"key":"e_1_2_1_6_2","first-page":"669","article-title":"ROLE OF DIFFERENT BRAIN STRUCTURES IN THE EXPRESSION OF THE PHYSICAL MORPHINE-WITHDRAWAL SYNDROME","volume":"261","author":"MALDONADO R","year":"1992","unstructured":"MALDONADO R, ROLE OF DIFFERENT BRAIN STRUCTURES IN THE EXPRESSION OF THE PHYSICAL MORPHINE-WITHDRAWAL SYNDROME, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 261, 669 (1992).","journal-title":"JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1126\/science.273.5275.657","volume":"273","author":"MALDONADO R","year":"1996","unstructured":"MALDONADO R, SCIENCE 273, 658 (1996).","journal-title":"SCIENCE"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S0896-6273(00)80110-5","article-title":"Under siege: The brain on opiates","volume":"16","author":"NESTLER E.J.","year":"1996","unstructured":"NESTLER E.J., Under siege: The brain on opiates, NEURON 16, 897 (1996).","journal-title":"NEURON"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/S0896-6273(00)80110-5","volume":"16","author":"NESTLER E.J.","year":"1996","unstructured":"NESTLER E.J., NEURON 16, 901 (1996).","journal-title":"NEURON"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.273.5275.611","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T04:24:33Z","timestamp":1705119873000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.273.5275.611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,8,2]]},"references-count":8,"journal-issue":{"issue":"5275","published-print":{"date-parts":[[1996,8,2]]}},"alternative-id":["10.1126\/science.273.5275.611"],"URL":"https:\/\/doi.org\/10.1126\/science.273.5275.611","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,8,2]]}}}