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Thus, pycnodysostosis results from gene defects in a lysosomal protease with highest expression in osteoclasts. These findings suggest that cathepsin K is a major protease in bone resorption, providing a possible rationale for the treatment of disorders such as osteoporosis and certain forms of arthritis.<\/jats:p>","DOI":"10.1126\/science.273.5279.1236","type":"journal-article","created":{"date-parts":[[2006,10,27]],"date-time":"2006-10-27T14:30:41Z","timestamp":1161959441000},"page":"1236-1238","source":"Crossref","is-referenced-by-count":873,"title":["Pycnodysostosis, a Lysosomal Disease Caused by Cathepsin K Deficiency"],"prefix":"10.1126","volume":"273","author":[{"given":"Bruce D.","family":"Gelb","sequence":"first","affiliation":[{"name":"B. D. Gelb and R. J. 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