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When TAg expression was silenced after 7 months, however, the hyperplasia persisted even though TAg was absent. Although the polyploidy of ductal cells could be reversed at 4 months of age, cells at 7 months of age remained polyploid even in the absence of TAg. These results support a model of time-dependent multistep tumorigenesis, in which virally transformed cells eventually lose their dependence on the viral oncoprotein for maintenance of the transformed state.<\/jats:p>","DOI":"10.1126\/science.273.5280.1384","type":"journal-article","created":{"date-parts":[[2006,10,27]],"date-time":"2006-10-27T18:30:41Z","timestamp":1161973841000},"page":"1384-1386","source":"Crossref","is-referenced-by-count":191,"title":["Time-Sensitive Reversal of Hyperplasia in Transgenic Mice Expressing SV40 T Antigen"],"prefix":"10.1126","volume":"273","author":[{"given":"Dagmar","family":"Ewald","sequence":"first","affiliation":[{"name":"D. Ewald and L. 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