{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:45:52Z","timestamp":1790286352613,"version":"4.1.0"},"reference-count":40,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5281","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1996,9,13]]},"abstract":"<jats:p>\n            The neuropeptide corticotropin-releasing factor (CRF) is well known to act on the central nervous system in ways that mimic stress and result in decreases in exploration, increases in sympathetic activity, decreases in parasympathetic outflow, and decreases in appetitive behavior. Urocortin, a neuropeptide related to CRF, binds with high affinity to the CRF\n            <jats:sub>2<\/jats:sub>\n            receptor, is more potent than CRF in suppressing appetite, but is less potent than CRF in producing anxiety-like effects and activation. Doses as low as 10 nanograms injected intracerebroventricularly were effective in decreasing food intake in food-deprived and free-feeding rats. These results suggest that urocortin may be an endogenous CRF-like factor in the brain responsible for the effects of stress on appetite.\n          <\/jats:p>","DOI":"10.1126\/science.273.5281.1561","type":"journal-article","created":{"date-parts":[[2006,10,27]],"date-time":"2006-10-27T18:30:41Z","timestamp":1161973841000},"page":"1561-1564","source":"Crossref","is-referenced-by-count":475,"title":["Appetite-Suppressing Effects of Urocortin, a CRF-Related Neuropeptide"],"prefix":"10.1126","volume":"273","author":[{"given":"Mariarosa","family":"Spina","sequence":"first","affiliation":[{"name":"M. Spina, E. Merlo-Pich, A. M. Basso, G. F. Koob, Department of Neuropharmacology, The Scripps Research Institute, 10666 North Torrey Pines Road, La Jolla, CA 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Merlo-Pich","sequence":"additional","affiliation":[{"name":"M. Spina, E. Merlo-Pich, A. M. Basso, G. F. Koob, Department of Neuropharmacology, The Scripps Research Institute, 10666 North Torrey Pines Road, La Jolla, CA 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond K. W.","family":"Chan","sequence":"additional","affiliation":[{"name":"R. K. W. Chan, Laboratory of Neuronal Structure and Function, The Salk Institute, La Jolla, CA 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria","family":"Basso","sequence":"additional","affiliation":[{"name":"M. Spina, E. Merlo-Pich, A. M. Basso, G. F. Koob, Department of Neuropharmacology, The Scripps Research Institute, 10666 North Torrey Pines Road, La Jolla, CA 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Rivier","sequence":"additional","affiliation":[{"name":"J. Rivier and W. Vale, Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, CA 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wylie","family":"Vale","sequence":"additional","affiliation":[{"name":"J. Rivier and W. Vale, Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, CA 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George F.","family":"Koob","sequence":"additional","affiliation":[{"name":"M. Spina, E. Merlo-Pich, A. M. Basso, G. F. 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