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All homozygous mutant mice developed antropyloric adenoma, and 30 percent developed multifocal intraepithelial or intramucosal carcinomas. The small intestine was characterized by enlarged villi and an abnormal infiltrate of lymphoid cells. These results indicate that\n            <jats:italic>mpS2<\/jats:italic>\n            is essential for normal differentiation of the antral and pyloric gastric mucosa and may function as a gastric-specific tumor suppressor gene.\n          <\/jats:p>","DOI":"10.1126\/science.274.5285.259","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:37:46Z","timestamp":1027762666000},"page":"259-262","source":"Crossref","is-referenced-by-count":428,"title":["Gastric Mucosa Abnormalities and Tumorigenesis in Mice Lacking the pS2 Trefoil Protein"],"prefix":"10.1126","volume":"274","author":[{"given":"Olivier","family":"Lefebvre","sequence":"first","affiliation":[{"name":"O. Lefebvre, R. Masson, J. Linares, A. Dierich, M. 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