{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:32:07Z","timestamp":1791275527203,"version":"4.1.0"},"reference-count":25,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4915","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1989,7,21]]},"abstract":"<jats:p>\n                    To characterize cell surface molecules involved in control of growth of malignant lymphocytes, monoclonal antibodies were raised against the human B lymphoblast cell line SKW6.4. One monoclonal antibody, anti-APO-1, reacted with a 52-kilodalton antigen (APO-1) on a set of activated human lymphocytes, on malignant human lymphocyte lines, and on some patient-derived leukemic cells. Nanogram quantities of anti-APO-1 completely blocked proliferation of cells bearing APO-1 in vitro in a manner characteristic of a process called programmed cell death or apoptosis. Cell death was preceded by changes in cell morphology and fragmentation of DNA. This process was distinct from antibody- and complement-dependent cell lysis and was mediated by the antibody alone. A single intravenous injection of anti-APO-1 into\n                    <jats:italic>nu<\/jats:italic>\n                    \/\n                    <jats:italic>nu<\/jats:italic>\n                    mice carrying a xenotransplant of a human B cell tumor induced regression of this tumor within a few days. Histological thin sections of the regressing tumor showed that anti-APO-1 was able to induce apoptosis in vivo. Thus, induction of apoptosis as a consequence of a signal mediated through cell surface molecules like APO-1 may be a useful therapeutic approach in treatment of malignancy.\n                  <\/jats:p>","DOI":"10.1126\/science.2787530","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T17:21:28Z","timestamp":1160068888000},"page":"301-305","source":"Crossref","is-referenced-by-count":1328,"title":["Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis"],"prefix":"10.1126","volume":"245","author":[{"given":"Bernhard C.","family":"Trauth","sequence":"first","affiliation":[{"name":"Institute for Immunology and Genetics, German Cancer Research Center, Heidelberg, Federal Republic of Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Klas","sequence":"additional","affiliation":[{"name":"Institute for Immunology and Genetics, German Cancer Research Center, Heidelberg, Federal Republic of Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke M. J.","family":"Peters","sequence":"additional","affiliation":[{"name":"Institute for Immunology and Genetics, German Cancer Research Center, Heidelberg, Federal Republic of Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siegfried","family":"Matzku","sequence":"additional","affiliation":[{"name":"Institute for Radiology and Pathophysiology, German Cancer Research Center, Heidelberg, Federal Republic of Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"M\u00f6ller","sequence":"additional","affiliation":[{"name":"Institute for Pathology of the University of Heidelberg, Federal Republic of Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Falk","sequence":"additional","affiliation":[{"name":"Institute for Immunology and Genetics, German Cancer Research Center, Heidelberg, Federal Republic of Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus-Michael","family":"Debatin","sequence":"additional","affiliation":[{"name":"Oncology\/Immunology Section, University Children's Hospital, Heidelberg, Federal Republic of Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H.","family":"Krammer","sequence":"additional","affiliation":[{"name":"Institute for Immunology and Genetics, German Cancer Research Center, Heidelberg, Federal Republic of Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1182\/blood.V73.3.651.651","volume":"73","year":"1989","unstructured":"BROWN, S.L., TREATMENT OF B-CELL LYMPHOMAS WITH ANTI-IDIOTYPE ANTIBODIES ALONE AND IN COMBINATION WITH ALPHA INTERFERON, BLOOD 73: 651 (1989).","journal-title":"BLOOD"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1002\/eji.1830170517","volume":"17","year":"1987","unstructured":"DEALTRY, G.B., DNA FRAGMENTATION AND CYTOTOXICITY CAUSED BY TUMOR-NECROSIS-FACTOR IS ENHANCED BY INTERFERON-GAMMA, EUROPEAN JOURNAL OF IMMUNOLOGY 17: 689 (1987).","journal-title":"EUROPEAN JOURNAL OF IMMUNOLOGY"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/icb.1977.38","volume":"55","year":"1977","unstructured":"DON, M.M., DEATH OF CELLS BY APOPTOSIS FOLLOWING ATTACHMENT OF SPECIFICALLY ALLERGIZED LYMPHOCYTES INVITRO, AUSTRALIAN JOURNAL OF EXPERIMENTAL BIOLOGY AND MEDICAL SCIENCE 55: 407 (1977).","journal-title":"AUSTRALIAN JOURNAL OF EXPERIMENTAL BIOLOGY AND MEDICAL SCIENCE"},{"key":"e_1_2_1_4_1","first-page":"6361","volume":"80","year":"1983","unstructured":"Duke, R. 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