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Selenium was incorporated into this protein during biosynthesis, and a characteristic stem-loop structure near the end of the messenger RNA was required for alternative selenocysteine decoding of a potential UGA stop codon within the open reading frame. The selenoprotein protected human keratinocytes against cytotoxic effects of ultraviolet irradiation and hydrogen peroxide, providing a mechanism for a virus to defend itself against environmental stress.<\/jats:p>","DOI":"10.1126\/science.279.5347.102","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:37:46Z","timestamp":1027762666000},"page":"102-105","source":"Crossref","is-referenced-by-count":141,"title":["Ultraviolet-Induced Cell Death Blocked by a Selenoprotein from a Human Dermatotropic Poxvirus"],"prefix":"10.1126","volume":"279","author":[{"given":"Joanna L.","family":"Shisler","sequence":"first","affiliation":[{"name":"J. L. Shisler, T. G. Senkevich, B. 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Supported in part by NIH grant DK47320 (M.J.B.)."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.279.5347.102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T04:56:18Z","timestamp":1705121778000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.279.5347.102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,1,2]]},"references-count":36,"journal-issue":{"issue":"5347","published-print":{"date-parts":[[1998,1,2]]}},"alternative-id":["10.1126\/science.279.5347.102"],"URL":"https:\/\/doi.org\/10.1126\/science.279.5347.102","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,1,2]]}}}