{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T08:30:03Z","timestamp":1717921803660},"reference-count":12,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5443","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1999,11,12]]},"DOI":"10.1126\/science.286.5443.1297e","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:49:42Z","timestamp":1027763382000},"page":"1297-1297","source":"Crossref","is-referenced-by-count":5,"title":["Tuberculosis Vaccines"],"prefix":"10.1126","volume":"286","author":[{"given":"Ren\u00e9e","family":"Ridzon","sequence":"first","affiliation":[{"name":"Centers for Disease Control and Prevention, Atlanta, GA 30333, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Hannan","sequence":"additional","affiliation":[{"name":"St. Mary's Hospital at Paddington, London W2 1NY, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","first-page":"877","volume":"77","author":"Palmer C. E.","year":"1958","unstructured":"Palmer C. E., et al., Am. Rev. Tuberc.77, 877 (1958).","journal-title":"Am. Rev. Tuberc."},{"key":"e_1_3_1_3_2","unstructured":"Ind. J. Med. Res. 72S 1 (1980)."},{"key":"e_1_4_3_1_2_2","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/38151","volume":"399","author":"Behr M. A.","year":"1997","unstructured":"Behr M. A., Small P. M., Nature399, 133 (1997).","journal-title":"Nature"},{"key":"e_1_4_3_1_3_2","unstructured":"\u201cThe Comstock Conference Report \u201d The Comstock Conference Baltimore MD 11 June 1996 (The Robert Wood Johnson Foundation Princeton NJ 1996)."},{"key":"e_1_4_3_1_4_2","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1001\/jama.1994.03510330076038","volume":"271","author":"Colditz G. A.","year":"1994","unstructured":"Colditz G. A., et al., J. Am. Med. Assoc.271, 698 (1994).","journal-title":"J. Am. Med. Assoc."},{"key":"e_1_4_3_1_5_2","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1126\/science.8073271","volume":"265","author":"Cohen J.","year":"1994","unstructured":"Cohen J., Science265, 1371 (1994).","journal-title":"Science"},{"key":"e_1_4_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.273.5274.497"},{"key":"e_1_4_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0895-815"},{"key":"e_1_4_3_1_8_2","author":"Lietman T.","unstructured":"Lietman T., Blower S., Clin. Infect. Dis., in press.","journal-title":"Clin. Infect. Dis."},{"key":"e_1_5_3_1_2_2","unstructured":"Using the model in (6) we have derived the following expression. To ensure the elimination of TB it is sufficient that the average number of new infectious cases caused by a single infectious case is less than unity or R 0 (1 - F T )(1 - F V E ) < 1 where R 0 is the average number of infectious cases caused by a single infectious case of TB in the absence of vaccination and treatment F T is the fraction effectively treated with antibiotics F V is the vaccination coverage level and E is the efficacy of the vaccine. Thus the effect of treatment (1 - F T )and the effect of vaccination (1 - F V E ) have a multiplicative effect on reducing R 0 . For the examples in the text we have assumed vaccine coverage of 88% (1) and an R 0 of 6.0 (5)."},{"key":"e_1_5_3_1_3_2","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1086\/314690","volume":"179","author":"Van Loo I. H.","year":"1999","unstructured":"Van Loo I. H., et al., J. Infect. Dis.179, 915 (1999).","journal-title":"J. Infect. Dis."},{"key":"e_1_5_3_1_4_2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/clinids\/20.1.11","volume":"20","author":"Fine P.E. M.","year":"1995","unstructured":"Fine P.E. M., Clin. Infect. Dis.20, 11 (1995).","journal-title":"Clin. Infect. Dis."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/full\/10.1126\/science.286.5443.1297e","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T10:32:01Z","timestamp":1705141921000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.286.5443.1297e"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,11,12]]},"references-count":12,"journal-issue":{"issue":"5443","published-print":{"date-parts":[[1999,11,12]]}},"alternative-id":["10.1126\/science.286.5443.1297e"],"URL":"https:\/\/doi.org\/10.1126\/science.286.5443.1297e","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,11,12]]}}}