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Because most patients with schizophrenia are treated with neuroleptic drugs that block D\n            <jats:sub>2<\/jats:sub>\n            dopamine receptors in the caudate nucleus, it has been suggested that this increase in the number of receptors is a result of adaptation to these drugs rather than a biochemical abnormality intrinsic to schizophrenia. With positron emission tomography (PET), the D\n            <jats:sub>2<\/jats:sub>\n            dopamine receptor density in the caudate nucleus of living human beings was measured in normal volunteers and in two groups of patients with schizophrenia\u2014one group that had never been treated with neuroleptics and another group that had been treated with these drugs. D\n            <jats:sub>2<\/jats:sub>\n            dopamine receptor densities in the caudate nucleus were higher in both groups of patients than in the normal volunteers. Thus, schizophrenia itself is associated with an increase in brain D\n            <jats:sub>2<\/jats:sub>\n            dopamine receptor density.\n          <\/jats:p>","DOI":"10.1126\/science.2878495","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T20:28:52Z","timestamp":1160080132000},"page":"1558-1563","source":"Crossref","is-referenced-by-count":784,"title":["Positron Emission Tomography Reveals Elevated D\n            <sub>2<\/sub>\n            Dopamine Receptors in Drug-Naive Schizophrenics"],"prefix":"10.1126","volume":"234","author":[{"given":"Dean F.","family":"Wong","sequence":"first","affiliation":[{"name":"Division of Nuclear Medicine, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205."},{"name":"Division of Radiation Health Sciences, Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Henry N.","family":"Wagner","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205."},{"name":"Division of Radiation Health Sciences, Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry E.","family":"Tune","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21205."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F","family":"Dannals","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205."},{"name":"Division of Radiation Health Sciences, Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Godfrey D.","family":"Pearlson","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21205."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M.","family":"Links","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205."},{"name":"Division of Radiation Health Sciences, Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol A.","family":"Tamminga","sequence":"additional","affiliation":[{"name":"University of Maryland Psychiatric Research Center, Baltimore, MD 21201."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel P","family":"Broussolle","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205."},{"name":"National Institute of Drug Abuse, Addiction Research Center, Baltimore, MD 21224"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayden T.","family":"Ravert","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205."},{"name":"Division of Radiation Health Sciences, Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan A.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205."},{"name":"Division of Radiation Health Sciences, Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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