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Because the blood-brain and blood-cerebrospinal fluid barriers are involved in normal water movements in the central nervous system, these studies suggest that brain barrier tissues may be important end organs for the atriopeptins and that atriopeptins could have therapeutic application to disorders of water balance in the central nervous system. An isolated, purified population of atriopeptin receptor cells, obtained from choroid epithelium, was used in these experiments. This cell population may provide a valuable model system for investigating the intracellular biochemical mechanisms through which atriopeptins exert their actions.<\/jats:p>","DOI":"10.1126\/science.2879355","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T20:28:58Z","timestamp":1160080138000},"page":"470-473","source":"Crossref","is-referenced-by-count":128,"title":["Brain Barrier Tissues: End Organs for Atriopeptins"],"prefix":"10.1126","volume":"235","author":[{"given":"Luca","family":"Steardo","sequence":"first","affiliation":[{"name":"Department of Neurology, Harvard Medical School, and Neuropharmacology Research Laboratory, Massachusetts General Hospital, Boston, MA 02114."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.","family":"Nathanson","sequence":"additional","affiliation":[{"name":"Department of Neurology, Harvard Medical School, and Neuropharmacology Research Laboratory, Massachusetts General Hospital, Boston, MA 02114."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1113\/jphysiol.1968.sp008660","volume":"199","year":"1968","unstructured":"ASHCROFT, G.W., ACTIVE TRANSPORT OF 5-HYDROXYINDOL-3-YLACETIC ACID AND 3-METHOXY-4-HYDROXYPHENYLACETIC ACID FROM A RECIRCULATORY PERFUSION SYSTEM OF CEREBRAL VENTRICLES OF UNANAESTHETIZED DOG, JOURNAL OF PHYSIOLOGY-LONDON 199: 397 (1968).","journal-title":"JOURNAL OF PHYSIOLOGY-LONDON"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1210\/edrv-6-2-107","volume":"6","year":"1985","unstructured":"CANTIN, M, THE HEART AND THE ATRIAL NATRIURETIC FACTOR, ENDOCRINE REVIEWS 6: 107 (1985).","journal-title":"ENDOCRINE REVIEWS"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2932797"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/0006-291X(70)90193-2","volume":"41","year":"1970","unstructured":"FERRENDELLI, J.A., EFFECT OF OXOTREMORINE AND ATROPINE ON CGMP AND CAMP LEVELS IN MOUSE CEREBRAL CORTEX AND CEREBELLUM, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 41: 1061 (1970).","journal-title":"BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS"},{"key":"e_1_2_1_5_1","first-page":"899","volume":"10","year":"1984","unstructured":"GABUZDA, D.H., SOCIETY FOR NEUROSCIENCE. 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