{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:19:13Z","timestamp":1791220753365,"version":"4.1.0"},"reference-count":22,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5475","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2000,6,30]]},"abstract":"<jats:p>With the escalation of obesity-related disease, there is great interest in defining the mechanisms that control appetite and body weight. We have identified a link between anabolic energy metabolism and appetite control. Both systemic and intracerebroventricular treatment of mice with fatty acid synthase (FAS) inhibitors (cerulenin and a synthetic compound C75) led to inhibition of feeding and dramatic weight loss. C75 inhibited expression of the prophagic signal neuropeptide Y in the hypothalamus and acted in a leptin-independent manner that appears to be mediated by malonyl\u2013coenzyme A. Thus, FAS may represent an important link in feeding regulation and may be a potential therapeutic target.<\/jats:p>","DOI":"10.1126\/science.288.5475.2379","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T05:40:50Z","timestamp":1027748450000},"page":"2379-2381","source":"Crossref","is-referenced-by-count":842,"title":["Reduced Food Intake and Body Weight in Mice Treated with Fatty Acid Synthase Inhibitors"],"prefix":"10.1126","volume":"288","author":[{"given":"Thomas M.","family":"Loftus","sequence":"first","affiliation":[{"name":"Department of Biological Chemistry,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna E.","family":"Jaworsky","sequence":"additional","affiliation":[{"name":"Department of Neuroscience,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gojeb L.","family":"Frehywot","sequence":"additional","affiliation":[{"name":"Department of Chemistry, The Johns Hopkins University, Baltimore, MD 21218, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig A.","family":"Townsend","sequence":"additional","affiliation":[{"name":"Department of Chemistry, The Johns Hopkins University, Baltimore, MD 21218, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele V.","family":"Ronnett","sequence":"additional","affiliation":[{"name":"Department of Neuroscience,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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Supported by NIH grants DK09623 (T.M.L.) and DC02979 (G.V.R.) the NIDDK (M.D.L.) the W. M. 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