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The high spontaneous incidence of this disease, together with the diverse clinical and pathologic features associated with it, suggests that environmental factors may account for some of the observed cases. Multiple tumors developed simultaneously in the transgenic<jats:italic>tat<\/jats:italic>mice at approximately 3 months of age, and the phenotype was successfully passed through three generations. The tumors arise from the nerve sheaths of peripheral nerves and are composed of perineural cells and fibroblasts. Tumor cells from these mice adapt easily to propagation in culture and continue to express the tat protein in significant amounts. When transplanted into nude mice, these cultured cells efficiently induce tumors. Evidence of HTLV-1 infection in patients with neural and other soft tissue tumors is needed in order to establish a link between infection by this human retrovirus and von Recklinghausen's disease and other nonlymphoid tumors.<\/jats:p>","DOI":"10.1126\/science.2888191","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T20:28:58Z","timestamp":1160080138000},"page":"1340-1343","source":"Crossref","is-referenced-by-count":200,"title":["A Transgenic Mouse Model for Human Neurofibromatosis"],"prefix":"10.1126","volume":"237","author":[{"given":"Steven H.","family":"Hinrichs","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Virology, National Cancer Institute, Bethesda, MD 20892."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Nerenberg","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Virology, National Cancer Institute, Bethesda, MD 20892."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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