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To examine this latter possibility, atrial natriuretic factor was used in alkalotic rats to restore a more normal GFR and to increase the amount of bicarbonate filtered by the glomerulus. Proximal bicarbonate reabsorption remained relatively static. Higher than normal amounts of bicarbonate were then delivered out of the proximal tubule, bicarbonate appeared in the urine, and the plasma concentration of bicarbonate fell. A reduction in GFR is thus necessary for the maintenance of chronic metabolic alkalosis. Normalizing GFR induces bicarbonaturia and initiates repair of the alkalosis.<\/jats:p>","DOI":"10.1126\/science.2930899","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T19:42:50Z","timestamp":1160077370000},"page":"1405-1407","source":"Crossref","is-referenced-by-count":22,"title":["Atrial Natriuretic Factor Ameliorates Chronic Metabolic Alkalosis by Increasing Glomerular Filtration"],"prefix":"10.1126","volume":"229","author":[{"given":"Martin G.","family":"Cogan","sequence":"first","affiliation":[{"name":"Cardiovascular Research Institute and Department of Medicine, University of California, San Francisco 94143"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1172\/JCI110821","volume":"71","year":"1983","unstructured":"ALPERN, R.J., EFFECTS OF EXTRACELLULAR FLUID VOLUME AND PLASMA BICARBONATE CONCENTRATION ON PROXIMAL ACIDIFICATION IN THE RAT, JOURNAL OF CLINICAL INVESTIGATION 71: 736 (1983).","journal-title":"JOURNAL OF CLINICAL INVESTIGATION"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/309717a0","volume":"309","year":"1984","unstructured":"ATLAS, S.A., PURIFICATION, SEQUENCING AND SYNTHESIS OF NATRIURETIC AND VASOACTIVE RAT ATRIAL PEPTIDE, NATURE 309: 717 (1984).","journal-title":"NATURE"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"F66","DOI":"10.1152\/ajprenal.1986.250.1.F66","volume":"250","year":"1986","unstructured":"Baum, M., American Journal of Physiology - 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