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Hybridization of tumor DNA with immunoglobulin gene probes revealed that each lymphoma was oligo- or monoclonal in origin and that individual tumors from the same animal arose from different B-cell clones. Thus the virus induced multiple transformation events in tamarins in vivo to cause malignant tumors resembling the Epstein-Barr virus-associated lymphomas of patients with organ transplants.<\/jats:p>","DOI":"10.1126\/science.2986287","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T15:42:50Z","timestamp":1160062970000},"page":"722-724","source":"Crossref","is-referenced-by-count":78,"title":["Individual Tumors of Multifocal EB Virus-Induced Malignant Lymphomas in Tamarins Arise from Different B-Cell Clones"],"prefix":"10.1126","volume":"228","author":[{"given":"M. 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