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Neither the nonpressor vasopressin analog 1-deamino-D-Arg\n            <jats:sup>8<\/jats:sup>\n            -vasopressin nor arginine-vasopressin in the presence of a specific pressor antagonist caused atriopeptin to be released into the circulation. Urine output was correlated with the level of atriopeptin released. Physiological levels of arginine-vasopressin suppress diuresis and produced vasoconstriction. Pharmacological levels of the hormone stimulated the cardiac endocrine system to release atriopeptin, which may cause diuresis and vasodilation to physiologically antagonize the effects of vasopressin.\n          <\/jats:p>","DOI":"10.1126\/science.2990050","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T19:42:50Z","timestamp":1160077370000},"page":"395-397","source":"Crossref","is-referenced-by-count":215,"title":["Vasopressin-Stimulated Release of Atriopeptin: Endocrine Antagonists in Fluid Homeostasis"],"prefix":"10.1126","volume":"229","author":[{"given":"Pamela T.","family":"Manning","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Monsanto Company, St. Louis, Missouri 63017"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Washington University Medical School, St. Louis, Missouri 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuo C.","family":"Katsube","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Washington University Medical School, St. Louis, Missouri 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra W.","family":"Holmberg","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Washington University Medical School, St. Louis, Missouri 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Needleman","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Washington University Medical School, St. Louis, Missouri 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","first-page":"746","volume":"196","year":"1976","unstructured":"CHAN, W.Y., INVESTIGATION OF NATRIURETIC, ANTIDIURETIC AND OXYTOCIC ACTIONS OF NEUROHYPOPHYSEAL HORMONES AND RELATED PEPTIDES - DELINEATION OF SEPARATE MECHANISMS OF ACTION AND ASSESSMENT OF MOLECULAR REQUIREMENTS, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 196: 746 (1976).","journal-title":"JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/0006-291X(84)91016-7","volume":"124","year":"1984","unstructured":"CURRIE, M.G., ATRIOPEPTIN RELEASE FROM THE ISOLATED PERFUSED RABBIT HEART, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 124: 711 (1984).","journal-title":"BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS"},{"key":"e_1_2_1_3_1","first-page":"1230","volume":"81","year":"1984","unstructured":"CURRIE, M.G., PROTEOLYTIC ACTIVATION OF A BIOACTIVE CARDIAC PEPTIDE BY INVITRO TRYPSIN CLEAVAGE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 81: 1230 (1984).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6857267"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6419347"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0024-3205(81)90370-2","volume":"28","year":"1981","unstructured":"DEBOLD, A.J., A RAPID AND POTENT NATRIURETIC RESPONSE TO INTRAVENOUS-INJECTION OF ATRIAL MYOCARDIAL EXTRACT IN RATS, LIFE SCIENCES 28: 89 (1981).","journal-title":"LIFE SCIENCES"},{"key":"e_1_2_1_7_1","unstructured":"Douglas W. 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