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This decrease in transcription is associated with a change in the chromatin structure of c-\n            <jats:italic>myc<\/jats:italic>\n            , as measured by deoxyribonuclease I (DNase I) hypersensitivity, and a shift of transcription from the LTR to the normal c-\n            <jats:italic>myc<\/jats:italic>\n            promoter. In contrast, cycloheximide had little or no effect on the transcription of LTR driven genes in infected chicken embryo fibroblasts treated with the drug. These results suggest that a labile, cell type-specific protein may interact with the retroviral LTR and regulate transcription of genes under LTR control. Further, the results demonstrate that the increase in intracellular concentration of c-\n            <jats:italic>myc<\/jats:italic>\n            RNA induced by cycloheximide treatment of normal cells is the result of stabilization of this message.\n          <\/jats:p>","DOI":"10.1126\/science.2999973","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T19:42:50Z","timestamp":1160077370000},"page":"1126-1132","source":"Crossref","is-referenced-by-count":281,"title":["Enhanced Transcription of c-\n            <i>myc<\/i>\n            in Bursal Lymphoma Cells Requires Continuous Protein Synthesis"],"prefix":"10.1126","volume":"230","author":[{"given":"Maxine","family":"Linial","sequence":"first","affiliation":[{"name":"Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Gunderson","sequence":"additional","affiliation":[{"name":"Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Groudine","sequence":"additional","affiliation":[{"name":"Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104"},{"name":"Department of Radiation Oncology, University of Washington School of Medicine, Seattle 98195."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","first-page":"105","volume":"17","year":"1974","unstructured":"AKIYAMA, Y, 2 CELL LINES FROM LYMPHOMAS OF MAREKS-DISEASE, BIKEN JOURNAL 17: 105 (1974).","journal-title":"BIKEN JOURNAL"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"4480","DOI":"10.1016\/S0021-9258(18)94343-7","volume":"244","year":"1969","unstructured":"Baliga, B. 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