{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:50:07Z","timestamp":1783511407160,"version":"3.55.0"},"reference-count":39,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4731","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1985,12,13]]},"abstract":"<jats:p>\n            Human granulocyte-macrophage colony-stimulating factor (GM-CSF) is a 22,000-dalton glycoprotein that stimulates the growth of myeloid progenitor cells and acts directly on mature neutrophils. A full-length complementary DNA clone encoding human GM-CSF was used as a probe to screen a human genomic library and isolate the gene encoding human GM-CSF. The human GM-CSF gene is approximately 2.5 kilobase pairs in length with at least three intervening sequences. The GM-CSF gene was localized by somatic cell hybrid analysis and in situ hybridization to human chromosome region 5q21-5q32, which is involved in interstitial deletions in the 5q\n            <jats:sup>-<\/jats:sup>\n            syndrome and acute myelogenous leukemia. An established, human promyelocytic leukemia cell line, HL60, contains a rearranged, partially deleted GM-CSF allele and a candidate 5q\n            <jats:sup>-<\/jats:sup>\n            marker chromosome, indicating that the truncated GM-CSF allele may reside at the rejoining point for the interstitial deletion on the HL60 marker chromosome.\n          <\/jats:p>","DOI":"10.1126\/science.2999978","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T19:42:50Z","timestamp":1160077370000},"page":"1282-1285","source":"Crossref","is-referenced-by-count":182,"title":["The Human Gene Encoding GM-CSF Is at 5q21-q32, the Chromosome Region Deleted in the 5q\n            <sup>-<\/sup>\n            Anomaly"],"prefix":"10.1126","volume":"230","author":[{"given":"Kay","family":"Huebner","sequence":"first","affiliation":[{"name":"The Wistar Institute, Philadelphia, Pennsylvania 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaharu","family":"Isobe","sequence":"additional","affiliation":[{"name":"The Wistar Institute, Philadelphia, Pennsylvania 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo M.","family":"Croce","sequence":"additional","affiliation":[{"name":"The Wistar Institute, Philadelphia, Pennsylvania 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Golde","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, School of Medicine, University of California, Los Angeles 90024"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan E.","family":"Kaufman","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, School of Medicine, University of California, Los Angeles 90024"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith C.","family":"Gasson","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, School of Medicine, University of California, Los Angeles 90024"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1182\/blood.V56.6.947.947","volume":"56","year":"1980","unstructured":"BURGESS, A.W., THE NATURE AND ACTION OF GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTORS, BLOOD 56: 947 (1980).","journal-title":"BLOOD"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1159\/000132079","volume":"38","year":"1984","unstructured":"CANNIZZARO, L.A., AN IMPROVED METHOD FOR G-BANDING CHROMOSOMES AFTER INSITU HYBRIDIZATION, CYTOGENETICS AND CELL GENETICS 38: 308 (1984).","journal-title":"CYTOGENETICS AND CELL GENETICS"},{"key":"e_1_2_1_3_1","first-page":"7006","volume":"80","year":"1983","unstructured":"Chen, I. 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