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When calcium ionophores were used in conjunction with direct activators of protein kinase C (12-\n            <jats:italic>O<\/jats:italic>\n            -tetradecanoyl phorbol-13-acetate and a synthetic diacylglycerol), a greater induction of viral antigens was observed than with either agent alone. Activation of protein kinase C may be required for the expression of the viral genome.\n          <\/jats:p>","DOI":"10.1126\/science.3012779","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T20:28:52Z","timestamp":1160080132000},"page":"1554-1556","source":"Crossref","is-referenced-by-count":105,"title":["Calcium Modulation Activates Epstein-Barr Virus Genome in Latently Infected Cells"],"prefix":"10.1126","volume":"232","author":[{"given":"Alberto","family":"Faggioni","sequence":"first","affiliation":[{"name":"Istituto di Patologia Generale, Universita degli Studi di Roma, \"La Sapienza,\" 00161 Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Zompetta","sequence":"additional","affiliation":[{"name":"Istituto di Patologia Generale, Universita degli Studi di Roma, \"La Sapienza,\" 00161 Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Settimio","family":"Grimaldi","sequence":"additional","affiliation":[{"name":"Istituto di Medicina Sperimentale del Consiglio Nazionale delle Ricerche, 00161 Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Barile","sequence":"additional","affiliation":[{"name":"Istituto di Tecnologie Biomediche del Consiglio Nazionale delle Ricerche, 00161 Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Frati","sequence":"additional","affiliation":[{"name":"Istituto di Patologia Generale, Universita degli Studi di Roma, \"La Sapienza,\" 00161 Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janis","family":"Lazdins","sequence":"additional","affiliation":[{"name":"Istituto di Patologia Generale, Universita degli Studi di Roma, \"La Sapienza,\" 00161 Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/0014-5793(86)80192-2","volume":"195","year":"1986","unstructured":"ADAMO, S, PROLIFERATING AND QUIESCENT CELLS EXHIBIT DIFFERENT SUBCELLULAR-DISTRIBUTION OF PROTEIN-KINASE-C ACTIVITY, FEBS LETTERS 195: 352 (1986).","journal-title":"FEBS LETTERS"},{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/312315a0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"7847","DOI":"10.1016\/S0021-9258(18)34459-4","volume":"257","year":"1982","unstructured":"CASTAGNA, M, DIRECT ACTIVATION OF CALCIUM-ACTIVATED, PHOSPHOLIPID-DEPENDENT PROTEIN-KINASE BY TUMOR-PROMOTING PHORBOL ESTERS, JOURNAL OF BIOLOGICAL CHEMISTRY 257: 7847 (1982).","journal-title":"JOURNAL OF BIOLOGICAL CHEMISTRY"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"3382","DOI":"10.4049\/jimmunol.133.6.3382","volume":"133","year":"1984","unstructured":"COGGESHALL, K.M., B-CELL ACTIVATION .8. 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