{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T11:55:31Z","timestamp":1762430131589},"reference-count":16,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4734","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1986,1,10]]},"abstract":"<jats:p>\n            In rats infected with the parasite\n            <jats:italic>Schistosoma mansoni<\/jats:italic>\n            , the concentration of C-reactive protein in the serum increases after the lung stage of infection and is at its highest at the time of terminal worm rejection. The peak of platelet-mediated cytotoxicity induced by infected serum that has been heated (and is free of immunoglobulin E) as well as the time course for the development of platelet cytotoxic activity in infected rats was found to be correlated with the concentration of C-reactive protein. Rat and human platelets treated with homologous serum obtained during an acute phase of inflammation or with purified C-reactive protein were able to kill the immature forms of the worm in vitro. Platelets treated with C-reactive protein were furthermore capable of conferring significant protection against schistosomiasis in transfer experiments. Collectively these data indicate that a system that includes C-reactive protein and platelets participates in the natural resistance of the rat to schistosomal infection.\n          <\/jats:p>","DOI":"10.1126\/science.3079916","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T20:28:52Z","timestamp":1160080132000},"page":"153-156","source":"Crossref","is-referenced-by-count":68,"title":["Rat Resistance to Schistosomiasis: Platelet-Mediated Cytotoxicity Induced by C-Reactive Protein"],"prefix":"10.1126","volume":"231","author":[{"given":"Daniel","family":"Bout","sequence":"first","affiliation":[{"name":"Centre d'Irmunologie et de Biologie Parasitaire, Institut Pasteur, 59019 Lille C\u00e9dex, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Joseph","sequence":"additional","affiliation":[{"name":"Centre d'Irmunologie et de Biologie Parasitaire, Institut Pasteur, 59019 Lille C\u00e9dex, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Pontet","sequence":"additional","affiliation":[{"name":"D\u00e9partemente de Biochimie, U.E.R. Biom\u00e9dicale des Saints-Pers, 75270 Paris Cedex, o6, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Vorng","sequence":"additional","affiliation":[{"name":"Centre d'Irmunologie et de Biologie Parasitaire, Institut Pasteur, 59019 Lille C\u00e9dex, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Desl\u00e9e","sequence":"additional","affiliation":[{"name":"Centre d'Irmunologie et de Biologie Parasitaire, Institut Pasteur, 59019 Lille C\u00e9dex, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Capron","sequence":"additional","affiliation":[{"name":"Centre d'Irmunologie et de Biologie Parasitaire, Institut Pasteur, 59019 Lille C\u00e9dex, France."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4049\/jimmunol.127.1.1","volume":"127","year":"1981","unstructured":"BOUT, D.T., INVITRO KILLING OF S MANSONI SCHISTOSOMULA BY LYMPHOKINE-ACTIVATED MOUSE MACROPHAGES, JOURNAL OF IMMUNOLOGY 127: 1 (1981).","journal-title":"JOURNAL OF IMMUNOLOGY"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1600-065X.1982.tb00373.x","volume":"61","year":"1982","unstructured":"CAPRON, A, EFFECTOR MECHANISMS OF IMMUNITY TO SCHISTOSOMES AND THEIR REGULATION, IMMUNOLOGICAL REVIEWS 61: 41 (1982).","journal-title":"IMMUNOLOGICAL REVIEWS"},{"key":"e_1_2_1_3_1","first-page":"55","volume":"45","year":"1982","unstructured":"DEBEER, F.C., ISOLATION AND CHARACTERIZATION OF C-REACTIVE PROTEIN AND SERUM AMYLOID-P COMPONENT IN THE RAT, IMMUNOLOGY 45: 55 (1982).","journal-title":"IMMUNOLOGY"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1749-6632.1982.tb22142.x","volume":"389","year":"1982","unstructured":"FIEDEL, B.A., EFFECTS OF C-REACTIVE PROTEIN (CRP) ON PLATELET-FUNCTION, ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 389: 263 (1982).","journal-title":"ANNALS OF THE NEW YORK ACADEMY OF SCIENCES"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1017\/S0031182000001347","volume":"89","year":"1984","unstructured":"FORD, M.J., IMMUNIZATION OF RATS AGAINST SCHISTOSOMA-MANSONI USING IRRADIATED CERCARIAE, LUNG SCHISTOSOMULA AND LIVER-STAGE WORMS, PARASITOLOGY 89: 327 (1984).","journal-title":"PARASITOLOGY"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/303810a0","volume":"303","year":"1983","unstructured":"JOSEPH, M, A NEW FUNCTION FOR PLATELETS - IGE-DEPENDENT KILLING OF SCHISTOSOMES, NATURE 303: 810 (1983).","journal-title":"NATURE"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1017\/S0031182000057152","volume":"86","year":"1983","unstructured":"KNOPF, P.M., RECOVERY OF PARASITES AT DIFFERENT STAGES OF MIGRATION FOLLOWING INFECTION OF RATS WITH SCHISTOSOMA-MANSONI, PARASITOLOGY 86: 37 (1983).","journal-title":"PARASITOLOGY"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1749-6632.1982.tb22126.x","volume":"389","year":"1982","unstructured":"MACINTYRE, S.S., BIOSYNTHESIS OF C-REACTIVE PROTEIN, ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 389: 76 (1982).","journal-title":"ANNALS OF THE NEW YORK ACADEMY OF SCIENCES"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0065-2776(08)60379-X","volume":"34","year":"1983","unstructured":"PEPYS, M.B., ACUTE PHASE PROTEINS WITH SPECIAL REFERENCE TO C-REACTIVE PROTEIN AND RELATED PROTEINS (PENTAXINS) AND SERUM AMYLOID A-PROTEIN, ADVANCES IN IMMUNOLOGY 34: 141 (1983).","journal-title":"ADVANCES IN IMMUNOLOGY"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/278259a0","volume":"278","year":"1979","unstructured":"PEPYS, M.B., SERUM AMYLOID P-COMPONENT IS AN ACUTE-PHASE REACTANT IN THE MOUSE, NATURE 278: 259 (1979).","journal-title":"NATURE"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/0005-2795(81)90135-5","volume":"671","year":"1981","unstructured":"PONTET, M, A NEW PENTRAXIN (SERUM AMYLOID P-COMPONENT) IN THE RAT - EVIDENCE FOR 2 QUATERNARY STRUCTURES AND EFFECT OF LIGANDS ON SELF-ASSOCIATION, BIOCHIMICA ET BIOPHYSICA ACTA 671: 202 (1981).","journal-title":"BIOCHIMICA ET BIOPHYSICA ACTA"},{"key":"e_1_2_1_12_1","first-page":"1190","volume":"44","year":"1985","unstructured":"POTEMPA, L. A., FEDERATION PROCEEDINGS 44: 1190 (1985).","journal-title":"FEDERATION PROCEEDINGS"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"571","DOI":"10.2307\/3275762","volume":"49","year":"1963","unstructured":"RITCHIE, L. S., JOURNAL OF PARASITOLOGY 49: 571 (1963).","journal-title":"JOURNAL OF PARASITOLOGY"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/S0021-9258(19)70074-X","volume":"256","year":"1981","unstructured":"ROBEY, F.A., LIMULIN - A C-REACTIVE PROTEIN FROM LIMULUS-POLYPHEMUS, JOURNAL OF BIOLOGICAL CHEMISTRY 256: 969 (1981).","journal-title":"JOURNAL OF BIOLOGICAL CHEMISTRY"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3966161"},{"key":"e_1_2_1_16_1","first-page":"527","year":"1982","unstructured":"SMITHERS, S.R., IMMUNOLOGY PARASITIC: 527 (1982).","journal-title":"IMMUNOLOGY PARASITIC"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.3079916","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T15:17:02Z","timestamp":1705159022000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.3079916"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,1,10]]},"references-count":16,"journal-issue":{"issue":"4734","published-print":{"date-parts":[[1986,1,10]]}},"alternative-id":["10.1126\/science.3079916"],"URL":"https:\/\/doi.org\/10.1126\/science.3079916","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,1,10]]}}}