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MPP\n            <jats:sup>+<\/jats:sup>\n            bound intracellularly to neuromelanin may be released gradually, resulting in subsequent damage to the neurons of the substantia nigra.\n          <\/jats:p>","DOI":"10.1126\/science.3080808","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T20:28:52Z","timestamp":1160080132000},"page":"987-989","source":"Crossref","is-referenced-by-count":264,"title":["Selectivity of the Parkinsonian Neurotoxin MPTP: Toxic Metabolite MPP\n            <sup>+<\/sup>\n            Binds to Neuromelanin"],"prefix":"10.1126","volume":"231","author":[{"given":"Robert J.","family":"D'Amato","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 2I205."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe P.","family":"Lipman","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 2I205."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solomon H.","family":"Snyder","sequence":"additional","affiliation":[{"name":"Departments of Neuroscience, Pharmacology and Experimental Therapeutics, and Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","first-page":"89","volume":"2","year":"1984","unstructured":"Bjorklund, A., Handbook of Chemcal Neuroanatomy 2: 89 (1984).","journal-title":"Handbook of Chemcal Neuroanatomy"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1017\/S0317167100046345","volume":"11","year":"1984","unstructured":"BURNS, R.S., THE NEUROTOXICITY OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE IN THE MONKEY AND MAN, CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES 11: 166 (1984).","journal-title":"CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES"},{"key":"e_1_2_1_3_1","first-page":"4546","volume":"80","year":"1983","unstructured":"Burns, R. S., Proceedings of the National Academy of Sciences of the United States of America 80: 4546 (1983).","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"e_1_2_1_4_1","first-page":"1457","volume":"2","year":"1983","unstructured":"CALNE, D.B., ETIOLOGY OF PARKINSONS-DISEASE, LANCET 2: 1457 (1983).","journal-title":"LANCET"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0024-3205(85)90063-3","volume":"36","year":"1985","unstructured":"CASTAGNOLI, N, POTENTIAL BIOACTIVATION PATHWAYS FOR THE NEUROTOXIN 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP), LIFE SCIENCES 36: 225 (1985).","journal-title":"LIFE SCIENCES"},{"key":"e_1_2_1_6_1","first-page":"713","volume":"23","year":"1964","unstructured":"COTZIAS, G.C., MELANOGENESIS + EXTRAPYRAMIDAL DISEASES, FEDERATION PROCEEDINGS 23: 713 (1964).","journal-title":"FEDERATION PROCEEDINGS"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1111\/j.1471-4159.1978.tb07814.x","volume":"30","year":"1978","unstructured":"DAS, K.C., NEURONAL PIGMENTS - SPECTROSCOPIC CHARACTERIZATION OF HUMAN-BRAIN MELANIN, JOURNAL OF NEUROCHEMISTRY 30: 601 (1978).","journal-title":"JOURNAL OF NEUROCHEMISTRY"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0165-1781(79)90006-4","volume":"1","year":"1979","unstructured":"DAVIS, G.C., CHRONIC PARKINSONISM SECONDARY TO INTRAVENOUS-INJECTION OF MEPERIDINE ANALOGS, PSYCHIATRY RESEARCH 1: 249 (1979).","journal-title":"PSYCHIATRY RESEARCH"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1471-4159.1985.tb07120.x","volume":"44","year":"1985","unstructured":"HALLMAN, H, NEUROCHEMICAL AND HISTOCHEMICAL CHARACTERIZATION OF NEUROTOXIC EFFECTS OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE ON BRAIN CATECHOLAMINE NEURONS IN THE MOUSE, JOURNAL OF NEUROCHEMISTRY 44: 117 (1985).","journal-title":"JOURNAL OF NEUROCHEMISTRY"},{"key":"e_1_2_1_10_1","first-page":"1","volume":"295","year":"1967","unstructured":"HAMBERGER, B, ACTA PHYSL SCAND 295: 1 (1967).","journal-title":"ACTA PHYSL SCAND"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/311467a0","volume":"311","year":"1984","unstructured":"HEIKKILA, R.E., PROTECTION AGAINST THE DOPAMINERGIC NEUROTOXICITY OF 1-METHYL-4-PHENYL-1,2,5,6-TETRAHYDROPYRIDINE BY MONOAMINE-OXIDASE INHIBITORS, NATURE 311: 467 (1984).","journal-title":"NATURE"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1523\/JNEUROSCI.05-06-01513.1985","volume":"5","year":"1985","unstructured":"JAVITCH, J.A., DIFFERENTIAL VISUALIZATION OF DOPAMINE AND NOREPINEPHRINE UPTAKE SITES IN RAT-BRAIN USING [H-3] MAZINDOL AUTORADIOGRAPHY, JOURNAL OF NEUROSCIENCE 5: 1513 (1985).","journal-title":"JOURNAL OF NEUROSCIENCE"},{"key":"e_1_2_1_13_1","first-page":"2173","volume":"82","year":"1985","unstructured":"JAVITCH, J.A., PARKINSONISM-INDUCING NEUROTOXIN, N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE - UPTAKE OF THE METABOLITE N-METHYL-4-PHENYLPYRIDINE BY DOPAMINE NEURONS EXPLAINS SELECTIVE TOXICITY, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 82: 2173 (1985).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_14_1","first-page":"4591","volume":"81","year":"1984","unstructured":"Javitch, J. 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