{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:56:33Z","timestamp":1761101793263},"reference-count":11,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4746","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1986,4,4]]},"abstract":"<jats:p>\n            The pathophysiology of anaphylaxis is very complex, and the sequelae of events are not fully explained in terms of the effects of histamine and peptide leukotrienes alone. Platelet-activating factor (1-\n            <jats:italic>O<\/jats:italic>\n            -alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine, PAF-acether) has been detected in animals undergoing anaphylaxis. Injection of synthetic PAF-acether induces similar effects, including bronchoconstriction, respiratory arrest, systemic hypotension, neutropenia, and thrombocytopenia. The results reported here demonstrate that the histamine- and leukotriene-independent component of guinea pig anaphylaxis in vivo and in isolated lung parenchymal strips in vitro is mediated by PAF-acether. However, PAF-acether is not responsible for the anaphylaxis-induced thrombocytopenia.\n          <\/jats:p>","DOI":"10.1126\/science.3082008","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T20:28:52Z","timestamp":1160080132000},"page":"58-60","source":"Crossref","is-referenced-by-count":89,"title":["Role of Platelet-Activating Factor-Acether in Mediating Guinea Pig Anaphylaxis"],"prefix":"10.1126","volume":"232","author":[{"given":"Harald","family":"Darius","sequence":"first","affiliation":[{"name":"Department of Physiology and Ischemia-Shock Research Institute, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Lefer","sequence":"additional","affiliation":[{"name":"Department of Physiology and Ischemia-Shock Research Institute, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Bryan","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Physiology and Ischemia-Shock Research Institute, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan M.","family":"Lefer","sequence":"additional","affiliation":[{"name":"Department of Physiology and Ischemia-Shock Research Institute, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/270255a0","volume":"270","year":"1977","unstructured":"ADAMS, G.K., ANTAGONISM OF ANTIGEN-INDUCED CONTRACTION OF GUINEA-PIG AND HUMAN AIRWAYS, NATURE 270: 255 (1977).","journal-title":"NATURE"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1084\/jem.136.6.1356","volume":"136","year":"1972","unstructured":"BENVENISTE, J, LEUKOCYTE-DEPENDENT HISTAMINE-RELEASE FROM RABBIT PLATELETS - ROLE OF IGE, BASOPHILS, AND A PLATELET-ACTIVATING FACTOR, JOURNAL OF EXPERIMENTAL MEDICINE 136: 1356 (1972).","journal-title":"JOURNAL OF EXPERIMENTAL MEDICINE"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1113\/jphysiol.1960.sp006449","volume":"151","year":"1960","unstructured":"BROCKLEHURST, W.E., THE RELEASE OF HISTAMINE AND FORMATION OF A SLOW-REACTING SUBSTANCE (SRS-A) DURING ANAPHYLACTIC SHOCK, JOURNAL OF PHYSIOLOGY-LONDON 151: 416 (1960).","journal-title":"JOURNAL OF PHYSIOLOGY-LONDON"},{"key":"e_1_2_1_4_1","first-page":"80","volume":"232","year":"1985","unstructured":"CHENG, J.B., TISSUE DISTRIBUTION AND FUNCTIONAL CORRELATION OF [H-3] LEUKOTRIENE-C4 AND [H-3] LEUKOTRIENE-D4 BINDING-SITES IN GUINEA-PIG UTERUS AND LUNG PREPARATIONS, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 232: 80 (1985).","journal-title":"JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6150550"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1476-5381.1984.tb10126.x","volume":"83","year":"1984","unstructured":"LEFER, A.M., PATHOPHYSIOLOGICAL MECHANISMS OF SUDDEN-DEATH INDUCED BY PLATELET ACTIVATING FACTOR, BRITISH JOURNAL OF PHARMACOLOGY 83: 125 (1984).","journal-title":"BRITISH JOURNAL OF PHARMACOLOGY"},{"key":"e_1_2_1_7_1","first-page":"303","volume":"45","year":"1981","unstructured":"MCMANUS, L.M., ACETYL GLYCERYL ETHER PHOSPHORYLCHOLINE - INTRAVASCULAR ALTERATIONS FOLLOWING INTRAVENOUS-INFUSION INTO THE BABOON, LABORATORY INVESTIGATION 45: 303 (1981).","journal-title":"LABORATORY INVESTIGATION"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.4049\/jimmunol.123.4.1847","volume":"123","year":"1979","unstructured":"PINCKARD, R.N., PHYSICOCHEMICAL AND FUNCTIONAL IDENTITY OF RABBIT PLATELET-ACTIVATING FACTOR (PAF) RELEASED INVIVO DURING IGE-ANAPHYLAXIS WITH PAF RELEASED INVITRO FROM IGE SENSITIZED BASOPHILS, JOURNAL OF IMMUNOLOGY 123: 1847 (1979).","journal-title":"JOURNAL OF IMMUNOLOGY"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6301011"},{"key":"e_1_2_1_10_1","first-page":"672","volume":"82","year":"1985","unstructured":"SHEN, T.Y., CHARACTERIZATION OF A PLATELET-ACTIVATING FACTOR RECEPTOR ANTAGONIST ISOLATED FROM HAIFENTENG (PIPER-FUTOKADSURA) - SPECIFIC-INHIBITION OF INVITRO AND INVIVO PLATELET-ACTIVATING FACTOR-INDUCED EFFECTS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 82: 672 (1985).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_11_1","first-page":"229","volume":"12","year":"1973","unstructured":"SMITH, G.M., BIBLIOTHECA ANATOMIC 12: 229 (1973).","journal-title":"BIBLIOTHECA ANATOMIC"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.3082008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T21:27:26Z","timestamp":1705181246000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.3082008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,4,4]]},"references-count":11,"journal-issue":{"issue":"4746","published-print":{"date-parts":[[1986,4,4]]}},"alternative-id":["10.1126\/science.3082008"],"URL":"https:\/\/doi.org\/10.1126\/science.3082008","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,4,4]]}}}