{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T16:47:47Z","timestamp":1771865267081,"version":"3.50.1"},"reference-count":30,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4776","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1986,10,31]]},"abstract":"<jats:p>\n            Mice immunized intradermally with extracts of\n            <jats:italic>Schistosoma mansoni<\/jats:italic>\n            in combination with the adjuvant BCG are significantly protected against subsequent infection with living larval forms of the parasite. Remarkably, these vaccinated animals produce antibodies predominantly against a single parasite protein of molecular weight 97 kilodaltons (Sm-97). A complementary DNA that encodes about half of the Sm-97 molecule has now been cloned and sequenced. Analysis of the deduced amino acid sequence reveals a protein containing periodic repeats of hydrophobic amino acids characteristic of an \u03b1-helical coiled-coil structure. The deduced amino acid composition of the cloned gene and several properties of the native protein are similar to that of paramyosin, an \u03b1-helical protein that forms the core for myosin filaments in invertebrate muscle. Paramyosin was isolated from\n            <jats:italic>Schistosoma mansoni<\/jats:italic>\n            adult worms and antibodies to Sm-97 were shown to react with this molecule as well as with a known paramyosin from molluscan muscle.\n          <\/jats:p>","DOI":"10.1126\/science.3094144","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T20:28:52Z","timestamp":1160080132000},"page":"593-596","source":"Crossref","is-referenced-by-count":125,"title":["Identification of Paramyosin as Schistosome Antigen Recognized by Intradermally Vaccinated Mice"],"prefix":"10.1126","volume":"234","author":[{"given":"David E.","family":"Lanar","sequence":"first","affiliation":[{"name":"Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward J.","family":"Pearce","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie L.","family":"James","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Microbiology George Washington University, Washington, DC 20037."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Sher","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1002\/eji.1830151205","volume":"15","year":"1985","unstructured":"AURIAULT, C, DEFINED ANTIGENS SECRETED BY THE LARVAE OF SCHISTOSOMES PROTECT AGAINST SCHISTOSOMIASIS - 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