{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T09:33:18Z","timestamp":1784194398830,"version":"3.55.0"},"reference-count":129,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4839","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1988,1,29]]},"abstract":"<jats:p>\n            Dengue viruses occur as four antigenically related but distinct serotypes transmitted to humans by\n            <jats:italic>Aedes aegypti<\/jats:italic>\n            mosquitoes. These viruses generally cause a benign syndrome, dengue fever, in the American and African tropics, and a severe syndrome, dengue hemorrhagic fever\/dengue shock syndrome (DHF\/DSS), in Southeast Asian children. This severe syndrome, which recently has also been identified in children infected with the virus in Puerto Rico, is characterized by increased vascular permeability and abnormal hemostasis. It occurs in infants less than 1 year of age born to dengue-immune mothers and in children 1 year and older who are immune to one serotype of dengue virus and are experiencing infection with a second serotype. Dengue viruses replicate in cells of mononuclear phagocyte lineage, and subneutralizing concentrations of dengue antibody enhance dengue virus infection in these cells. This antibody-dependent enhancement of infection regulates dengue disease in human beings, although disease severity may also be controlled genetically, possibly by permitting and restricting the growth of virus in monocytes. Monoclonal antibodies show heterogeneous distribution of antigenic epitopes on dengue viruses. These epitopes serve to regulate disease: when antibodies to shared antigens partially neutralize heterotypic virus, infection and disease are dampened; enhancing antibodies alone result in heightened disease response. Further knowledge of the structure of dengue genomes should permit rapid advances in understanding the pathogenetic mechanisms of dengue.\n          <\/jats:p>","DOI":"10.1126\/science.3277268","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T21:21:15Z","timestamp":1160083275000},"page":"476-481","source":"Crossref","is-referenced-by-count":645,"title":["Pathogenesis of Dengue: Challenges to Molecular Biology"],"prefix":"10.1126","volume":"239","author":[{"given":"Scott B.","family":"Halstead","sequence":"first","affiliation":[{"name":"Division of Health Sciences, Rockefeller Foundation, New York, NY 10036."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","first-page":"117","volume":"48","year":"1973","unstructured":"Bulletin of the World Health Organization 48: 117 (1973).","journal-title":"Bulletin of the World Health Organization"},{"key":"e_1_2_1_2_1","unstructured":"Computer survey of Stegomyia mosquitoes WHO Technical Report VBC\/73.11.50 (1973)."},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1099\/0022-1317-67-11-2539","volume":"67","year":"1986","unstructured":"BARRETT, ADT, ANTIBODY-MEDIATED EARLY DEATH INVIVO AFTER INFECTION WITH YELLOW-FEVER VIRUS, JOURNAL OF GENERAL VIROLOGY 67: 2539 (1986).","journal-title":"JOURNAL OF GENERAL VIROLOGY"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1080\/00034983.1967.11686519","volume":"61","year":"1967","unstructured":"BHAMARAPRAVATI, N, PATHOLOGY OF THAILAND HAEMORRHAGIC FEVER - A STUDY OF 100 AUTOPSY CASES, ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY 61: 500 (1967).","journal-title":"ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY"},{"key":"e_1_2_1_5_1","first-page":"189","volume":"65","year":"1987","unstructured":"BHAMARAPRAVATI, N, IMMUNIZATION WITH A LIVE ATTENUATED DENGUE-2-VIRUS CANDIDATE VACCINE (16681-PDK 53) - CLINICAL, IMMUNOLOGICAL AND BIOLOGICAL RESPONSES IN ADULT VOLUNTEERS, BULLETIN OF THE WORLD HEALTH ORGANIZATION 65: 189 (1987).","journal-title":"BULLETIN OF THE WORLD HEALTH ORGANIZATION"},{"key":"e_1_2_1_6_1","first-page":"50","volume":"35","year":"1966","unstructured":"BHAMARAPRAVATI, N, PATHOGENETIC STUDIES ON THAI HAEMORRHAGIC FEVER - IMMUNOFLUORESCENT LOCALIZATION OF DENGUE VIRUS IN HUMAN TISSUE, BULLETIN OF THE WORLD HEALTH ORGANIZATION 35: 50 (1966).","journal-title":"BULLETIN OF THE WORLD HEALTH ORGANIZATION"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1056\/NEJM197311082891902","volume":"289","year":"1973","unstructured":"BOKISCH, V.A., POTENTIAL PATHOGENIC ROLE OF COMPLEMENT IN DENGUE HEMORRHAGIC-SHOCK SYNDROME, NEW ENGLAND JOURNAL OF MEDICINE 289: 996 (1973).","journal-title":"NEW ENGLAND JOURNAL OF MEDICINE"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"881","DOI":"10.4269\/ajtmh.1979.28.881","volume":"28","year":"1979","unstructured":"BOONPUCKNAVIG, S, DEMONSTRATION OF DENGUE ANTIBODY COMPLEXES ON THE SURFACE OF PLATELETS FROM PATIENTS WITH DENGUE HEMORRHAGIC-FEVER, AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE 28: 881 (1979).","journal-title":"AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE"},{"key":"e_1_2_1_9_1","first-page":"37","volume":"85","year":"1976","unstructured":"BOONPUCKNAVIG, S, IMMUNOFLUORESCENT STAINING OF SURFACES OF LYMPHOCYTES IN SUSPENSION FROM PATIENTS WITH DENGUE HEMORRHAGIC-FEVER, AMERICAN JOURNAL OF PATHOLOGY 85: 37 (1976).","journal-title":"AMERICAN JOURNAL OF PATHOLOGY"},{"key":"e_1_2_1_10_1","first-page":"463","volume":"103","year":"1979","unstructured":"BOONPUCKNAVIG, S, ARCHIVES OF PATHOLOGY AND LABORATORY MEDICINE 103: 463 (1979).","journal-title":"ARCHIVES OF PATHOLOGY AND LABORATORY MEDICINE"},{"key":"e_1_2_1_11_1","first-page":"206","volume":"100","year":"1976","unstructured":"BOONPUCKNAVIG, V, GLOMERULAR CHANGES IN DENGUE HEMORRHAGIC-FEVER, ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE 100: 206 (1976).","journal-title":"ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1128\/iai.36.3.1036-1041.1982","volume":"36","year":"1982","unstructured":"BRANDT, W.E., INFECTION ENHANCEMENT OF DENGUE TYPE-2 VIRUS IN THE U-937 HUMAN MONOCYTE CELL-LINE BY ANTIBODIES TO FLAVIVIRUS CROSS-REACTIVE DETERMINANTS, INFECTION AND IMMUNITY 36: 1036 (1982).","journal-title":"INFECTION AND IMMUNITY"},{"key":"e_1_2_1_13_1","first-page":"259","volume":"37","year":"1985","unstructured":"BRAVO, J, REVISTA CUBANA DE MEDICINA TROPICAL 37: 259 (1985).","journal-title":"REVISTA CUBANA DE MEDICINA TROPICAL"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/0035-9203(87)90041-1","volume":"81","year":"1987","unstructured":"BRAVO, J.R., WHY DENGUE HEMORRHAGIC-FEVER IN CUBA .1. 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