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When newborn or adult NOD mice were infected with a lymphotropic virus they did not become diabetic. The interaction between viruses and lymphocytes is pivotal in aborting diabetes, as established by experiments in which lymphocytes from virus-infected donors failed to transfer diabetes. In contrast, lymphocytes from age- and sex-matched uninfected donors caused disease. Therefore, viruses and, presumably, their products can be developed to be beneficial and may have potential as a component for treatment of human diseases. Further, these results point to the utility of viruses as probes for dissecting the pathogenesis of a nonviral disease.<\/jats:p>","DOI":"10.1126\/science.3277269","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T21:21:15Z","timestamp":1160083275000},"page":"500-502","source":"Crossref","is-referenced-by-count":131,"title":["Prevention of Type I Diabetes in Nonobese Diabetic Mice by Virus Infection"],"prefix":"10.1126","volume":"239","author":[{"given":"Michael B. 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