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Blocking Notch signaling triggers astrocytes in the striatum and the medial cortex to enter a neurogenic program, even in the absence of stroke, resulting in 850 \u00b1 210 (mean \u00b1 SEM) new neurons in a mouse striatum. Thus, under Notch signaling regulation, astrocytes in the adult mouse brain parenchyma carry a latent neurogenic program that may potentially be useful for neuronal replacement strategies.<\/jats:p>","DOI":"10.1126\/science.346.6206.237","type":"journal-article","created":{"date-parts":[[2014,10,9]],"date-time":"2014-10-09T14:17:20Z","timestamp":1412864240000},"page":"237-241","source":"Crossref","is-referenced-by-count":423,"title":["A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse"],"prefix":"10.1126","volume":"346","author":[{"given":"Jens P.","family":"Magnusson","sequence":"first","affiliation":[{"name":"Department of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"G\u00f6ritz","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jemal","family":"Tatarishvili","sequence":"additional","affiliation":[{"name":"Lund Stem Cell Center, University Hospital, SE-221 84 Lund, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David O.","family":"Dias","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma M. 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