{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:05:04Z","timestamp":1791198304162,"version":"4.1.0"},"reference-count":43,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4792","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1987,2,27]]},"abstract":"<jats:p>\n            Deletions of the long arm of chromosome 6 (6q-) are frequently found in hematopoietic neoplasms, including acute lymphoblastic leukemias, non-Hodgkin lymphomas and (less frequently) myeloid leukemias. The c-\n            <jats:italic>myb<\/jats:italic>\n            proto-oncogene has been mapped to region 6q21-24, which suggests that it could be involved in the 6q- aberrations. By means of in situ chromosomal hybridization on cells from six hematopoietic malignancies, it was demonstrated that the c-\n            <jats:italic>myb<\/jats:italic>\n            locus is not deleted, but is retained on band q22, which is consistently bordered by the chromosomal breakpoints in both interstitial and terminal 6q- deletions. The deletion breakpoints were located at some distance from the\n            <jats:italic>myb<\/jats:italic>\n            locus since no rearrangement of c-\n            <jats:italic>myb<\/jats:italic>\n            sequences was found. In one case, however, amplification of the entire c-\n            <jats:italic>myb<\/jats:italic>\n            locus was detectable. Furthermore, in all cases tested that carry 6q- deletions,\n            <jats:italic>myb<\/jats:italic>\n            messenger RNA levels were significantly higher than in normal cells or in malignant cells matched for lineage and stage of differentiation but lacking the 6q- marker. These results indicate that 6q- deletions are accompanied by structural and functional alterations of the c-\n            <jats:italic>myb<\/jats:italic>\n            locus and that these alterations may be involved in the pathogenesis of leukemias and lymphomas.\n          <\/jats:p>","DOI":"10.1126\/science.3469751","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T20:28:58Z","timestamp":1160080138000},"page":"1064-1067","source":"Crossref","is-referenced-by-count":76,"title":["Relationship Between the c-\n            <i>myb<\/i>\n            Locus and the 6q- Chromosomal Aberration in Leukemias and Lymphomas"],"prefix":"10.1126","volume":"235","author":[{"given":"Cosimo","family":"Barletta","sequence":"first","affiliation":[{"name":"Department of Pathology and Kaplan Cancer Center, New York University School of Medicine, New York, NY 10016."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier-Giuseppe","family":"Pelicci","sequence":"additional","affiliation":[{"name":"Department of Pathology and Kaplan Cancer Center, New York University School of Medicine, New York, NY 10016."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence C.","family":"Kenyon","sequence":"additional","affiliation":[{"name":"Department of Pathology and Kaplan Cancer Center, New York University School of Medicine, New York, NY 10016."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen D.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Dalla-Favera","sequence":"additional","affiliation":[{"name":"Department of Pathology and Kaplan Cancer Center, New York University School of Medicine, New York, NY 10016."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0165-4608(81)90076-5","volume":"4","year":"1981","unstructured":"CANCER GENET CYTOGEN 4: 101 (1981).","journal-title":"CANCER GENET CYTOGEN"},{"key":"e_1_2_1_2_1","unstructured":"Bernards A. personal communication Second Annual Meeting on Oncogenes Frederick MD (1986)."},{"key":"e_1_2_1_3_1","first-page":"2975","volume":"43","year":"1983","unstructured":"BLOOMFIELD, C.D., NONRANDOM CHROMOSOME-ABNORMALITIES IN LYMPHOMA, CANCER RESEARCH 43: 2975 (1983).","journal-title":"CANCER RESEARCH"},{"key":"e_1_2_1_4_1","first-page":"593","volume":"1","year":"1984","unstructured":"CANAANI, E, ALTERED TRANSCRIPTION OF AN ONCOGENE IN CHRONIC MYELOID-LEUKEMIA, LANCET 1: 593 (1984).","journal-title":"LANCET"},{"key":"e_1_2_1_5_1","first-page":"4813","volume":"80","year":"1983","unstructured":"Collins, S. J., Proceedings of the National Academy of Sciences of the United States of America 80: 4813 (1983).","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"e_1_2_1_6_1","first-page":"442","volume":"44","year":"1984","unstructured":"CRAIG, R.W., EARLY DECLINE IN C-MYB ONCOGENE EXPRESSION IN THE DIFFERENTIATION OF HUMAN MYELOBLASTIC-LEUKEMIA (ML-1) CELLS INDUCED WITH 12-O-TETRADECANOYLPHORBOL-13-ACETATE, CANCER RESEARCH 44: 442 (1984).","journal-title":"CANCER RESEARCH"},{"key":"e_1_2_1_7_1","first-page":"7824","volume":"79","year":"1982","unstructured":"Dalla-Favera, R., Proceedings of the National Academy of Sciences of the United States of America 79: 7824 (1982).","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"e_1_2_1_8_1","first-page":"4714","volume":"79","year":"1982","unstructured":"DALLAFAVERA, R, CHROMOSOMAL ASSIGNMENT OF THE HUMAN HOMOLOGS OF FELINE SARCOMA-VIRUS AND AVIAN-MYELOBLASTOSIS VIRUS ONC GENES, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 79: 4714 (1982).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6401867"},{"key":"e_1_2_1_10_1","first-page":"5120","volume":"77","year":"1980","unstructured":"DUESBERG, P.H., GENETIC-STRUCTURE OF AVIAN-MYELOBLASTOSIS VIRUS, RELEASED FROM TRANSFORMED MYELOBLASTS AS A DEFECTIVE VIRUS PARTICLE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 77: 5120 (1980).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES"},{"key":"e_1_2_1_11_1","first-page":"69","volume":"4","year":"1984","unstructured":"FLINTOFF, W.F., MODERATE-LEVEL GENE AMPLIFICATION IN METHOTREXATE-RESISTANT CHINESE-HAMSTER OVARY CELLS IS ACCOMPANIED BY CHROMOSOMAL TRANSLOCATIONS AT OR NEAR THE SITE OF THE AMPLIFIED DHFR GENE, MOLECULAR AND CELLULAR BIOLOGY 4: 69 (1984).","journal-title":"MOLECULAR AND CELLULAR BIOLOGY"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1128\/mcb.2.6.617-624.1982","volume":"2","year":"1982","unstructured":"GONDA, T.J., TRANSCRIPTS FROM THE CELLULAR HOMOLOGS OF RETROVIRAL ONCOGENES - DISTRIBUTION AMONG CHICKEN TISSUES, MOLECULAR AND CELLULAR BIOLOGY 2: 617 (1982).","journal-title":"MOLECULAR AND CELLULAR BIOLOGY"},{"key":"e_1_2_1_13_1","first-page":"269","volume":"516","year":"1978","unstructured":"GRAF, T, AVIAN LEUKEMIA VIRUSES - INTERACTION WITH THEIR TARGET-CELLS INVIVO AND INVITRO, BIOCHIMICA ET BIOPHYSICA ACTA 516: 269 (1978).","journal-title":"BIOCHIMICA ET BIOPHYSICA ACTA"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/BF00327364","volume":"83","year":"1981","unstructured":"HARPER, M.E., LOCALIZATION OF SINGLE COPY DNA-SEQUENCES ON G-BANDED HUMAN-CHROMOSOMES BY INSITU HYBRIDIZATION, CHROMOSOMA 83: 431 (1981).","journal-title":"CHROMOSOMA"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/304169a0","volume":"304","year":"1983","unstructured":"HARPER, M.E., CHROMOSOMAL SUBLOCALIZATION OF HUMAN C-MYB AND C-FES CELLULAR ONC GENES, NATURE 304: 169 (1983).","journal-title":"NATURE"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/306239a0"},{"key":"e_1_2_1_17_1","first-page":"1","volume":"104","year":"1986","unstructured":"KRISTOFFERSSON, U, CYTOGENETIC STUDIES IN NON-HODGKIN LYMPHOMAS - RESULTS FROM SURGICAL BIOPSIES, HEREDITAS 104: 1 (1986).","journal-title":"HEREDITAS"},{"key":"e_1_2_1_18_1","first-page":"371","volume":"3","year":"1984","unstructured":"LEBEAU, M.M., RECURRING CHROMOSOMAL-ABNORMALITIES IN LEUKEMIA AND LYMPHOMA, CANCER SURVEYS 3: 371 (1984).","journal-title":"CANCER SURVEYS"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/312070a0","volume":"312","year":"1984","unstructured":"LEBEAU, M.M., EVIDENCE FOR 2 DISTINCT C-SRC LOCI ON HUMAN CHROMOSOME-1 AND CHROMOSOME-20, NATURE 312: 70 (1984).","journal-title":"NATURE"},{"key":"e_1_2_1_20_1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0092-8674(85)90138-2","volume":"40","year":"1985","unstructured":"LITTMAN, D.R., THE ISOLATION AND SEQUENCE OF THE GENE ENCODING T8 - A MOLECULE DEFINING FUNCTIONAL CLASSES OF LYMPHOCYTES-T, CELL 40: 237 (1985).","journal-title":"CELL"},{"key":"e_1_2_1_21_1","first-page":"9636","volume":"83","year":"1986","unstructured":"Majello, B., Proceedings of the National Academy of Sciences of the United States of America 83: 9636 (1986).","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"e_1_2_1_22_1","unstructured":"Minowada J. 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