{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:50:09Z","timestamp":1791273009454,"version":"4.1.0"},"reference-count":17,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4343","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1978,5,19]]},"abstract":"<jats:p>\n            A flame retardant used in children's sleepwear, tris-(1,3-dichloro-2-propyl)phosphate (Fyrol FR2) is a mutagen in the\n            <jats:italic>Salmonella<\/jats:italic>\n            -mammalian tissue homogenate test after it has been activated by mouse or rat liver homogenate. The expected enzymatic hydrolysis product, 1,3-dichloro-2-propanol, is similarly a mutagen after activation by liver homogenate. A proposed metabolite of the flame retardant, 1,3-dichloro-2-propanone, is a potent mutagen in the absence of such activation. A flame retardant with similar structure, tris-(2,3-dibromopropyl)phosphate (tris-BP), was shown previously to be a mutagen, to cause sterility in animals, to be a carcinogen, and to be absorbed through human skin. These and other flame retardants have characteristic nuclear magnetic resonance spectra that can be used to determine which flame retardant is present in commercially purchased sleepwear. Sleepwear treated with tris-BP, Fyrol FR2, and other chemical additives was being sold in late 1977.\n          <\/jats:p>","DOI":"10.1126\/science.347576","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T16:35:25Z","timestamp":1160066125000},"page":"785-787","source":"Crossref","is-referenced-by-count":143,"title":["Another Flame Retardant, Tris-(1,3-Dichloro-2-Propyl)-Phosphate, and Its Expected Metabolites Are Mutagens"],"prefix":"10.1126","volume":"200","author":[{"given":"Marian Deborah","family":"Gold","sequence":"first","affiliation":[{"name":"Biochemistry Department, University of California, Berkeley 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arlene","family":"Blum","sequence":"additional","affiliation":[{"name":"Biochemistry Department, University of California, Berkeley 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce N.","family":"Ames","sequence":"additional","affiliation":[{"name":"Biochemistry Department, University of California, Berkeley 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","first-page":"18852","volume":"42","year":"1977","unstructured":"Federal Register 42: 18852 (8 4 1977).","journal-title":"Federal Register"},{"key":"e_1_2_1_2_1","unstructured":"Summary of Program Staff and Data Evaluation (1977)."},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0165-1161(75)90046-1","volume":"31","year":"1975","unstructured":"AMES, B.N., METHODS FOR DETECTING CARCINOGENS AND MUTAGENS WITH SALMONELLA-MAMMALIAN-MICROSOME MUTAGENICITY TEST, MUTATION RESEARCH 31: 347 (1975).","journal-title":"MUTATION RESEARCH"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.831254"},{"key":"e_1_2_1_5_1","unstructured":"BLUM A UNPUBLISHED."},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1042\/bj1260701","volume":"126","year":"1972","unstructured":"DONNINGER, C, OXIDATIVE DEALKYLATION OF INSECTICIDAL PHOSPHORIC-ACID TRIESTERS BY MAMMALIAN LIVER ENZYMES, BIOCHEMICAL JOURNAL 126: 701 (1972).","journal-title":"BIOCHEMICAL JOURNAL"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/0041-008X(74)90137-9","volume":"28","year":"1974","unstructured":"FELDMANN, R.J., PERCUTANEOUS PENETRATION OF SOME PESTICIDES AND HERBICIDES IN MAN, TOXICOLOGY AND APPLIED PHARMACOLOGY 28: 126 (1974).","journal-title":"TOXICOLOGY AND APPLIED PHARMACOLOGY"},{"key":"e_1_2_1_8_1","first-page":"697","year":"1977","unstructured":"Hsieh, D. 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