{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T22:26:46Z","timestamp":1770503206109,"version":"3.49.0"},"reference-count":60,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4741","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1986,2,28]]},"abstract":"<jats:p>\n            By in situ chromosomal hybridization, the\n            <jats:italic>GM-CSF<\/jats:italic>\n            and\n            <jats:italic>FMS<\/jats:italic>\n            genes were localized to human chromosome 5 at bands q23 to q31, and at band 5q33, respectively. These genes encode proteins involved in the regulation of hematopoiesis, and are located within a chromosome region frequently deleted in patients with neoplastic myeloid disorders. Both genes were deleted in the 5q- chromosome from bone marrow cells of two patients with refractory anemia and a del(5)(q15q33.3). The\n            <jats:italic>GM-CSF<\/jats:italic>\n            gene alone was deleted in a third patient with acute nonlymphocytic leukemia (ANLL) who has a smaller deletion, del(5)(q22q33.1). Leukemia cells from a fourth patient who has ANLL and does not have a del(5q), but who has a rearranged chromosome 5 that is missing bands q31.3 to q33.1 [ins(21;5)(q22;q31.3q33.1)] were used to sublocalize these genes; both genes were present on the rearranged chromosome 5. Thus, the deletion of one or both of these genes may be important in the pathogenesis of myelodysplastic syndromes or of ANLL.\n          <\/jats:p>","DOI":"10.1126\/science.3484837","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T20:28:52Z","timestamp":1160080132000},"page":"984-987","source":"Crossref","is-referenced-by-count":175,"title":["Evidence for the Involvement of\n            <i>GM-CSF<\/i>\n            and\n            <i>FMS<\/i>\n            in the Deletion (5q) in Myeloid Disorders"],"prefix":"10.1126","volume":"231","author":[{"given":"Michelle M.","family":"Le Beau","sequence":"first","affiliation":[{"name":"Joint Section of Hematology\/Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol A.","family":"Westbrook","sequence":"additional","affiliation":[{"name":"Joint Section of Hematology\/Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel O.","family":"Diaz","sequence":"additional","affiliation":[{"name":"Joint Section of Hematology\/Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard A.","family":"Larson","sequence":"additional","affiliation":[{"name":"Joint Section of Hematology\/Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet D.","family":"Rowley","sequence":"additional","affiliation":[{"name":"Joint Section of Hematology\/Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith C.","family":"Gasson","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, School of Medicine, University of California, Los Angeles 90024."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David W.","family":"Golde","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, School of Medicine, University of California, Los Angeles 90024."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles J.","family":"Sherr","sequence":"additional","affiliation":[{"name":"Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN 38105."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0165-4608(84)90030-X","volume":"12","year":"1984","unstructured":"ARTHUR, D.C., BANDED CHROMOSOME ANALYSIS IN PATIENTS WITH TREATMENT-ASSOCIATED ACUTE NONLYMPHOCYTIC LEUKEMIA, CANCER GENETICS AND CYTOGENETICS 12: 189 (1984).","journal-title":"CANCER GENETICS AND CYTOGENETICS"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1128\/jvi.40.3.812-821.1981","volume":"40","year":"1981","unstructured":"BARBACID, M, GENE-PRODUCTS OF MCDONOUGH FELINE SARCOMA-VIRUS HAVE AN INVITRO-ASSOCIATED PROTEIN-KINASE THAT PHOSPHORYLATES TYROSINE RESIDUES - LACK OF DETECTION OF THIS ENZYMATIC-ACTIVITY INVIVO, JOURNAL OF VIROLOGY 40: 812 (1981).","journal-title":"JOURNAL OF VIROLOGY"},{"key":"e_1_2_1_3_1","first-page":"A200","volume":"14","year":"1984","unstructured":"BUNN, H.F., BLOOD 14: A200 (1984).","journal-title":"BLOOD"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1182\/blood.V56.6.947.947","volume":"56","year":"1980","unstructured":"BURGESS, A.W., THE NATURE AND ACTION OF GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTORS, BLOOD 56: 947 (1980).","journal-title":"BLOOD"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1016\/S0021-9258(18)71855-3","volume":"252","year":"1977","unstructured":"BURGESS, A.W., PURIFICATION AND PROPERTIES OF COLONY-STIMULATING FACTOR FROM MOUSE LUNG-CONDITIONED MEDIUM, JOURNAL OF BIOLOGICAL CHEMISTRY 252: 1998 (1977).","journal-title":"JOURNAL OF BIOLOGICAL CHEMISTRY"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1182\/blood.V66.1.189.189","volume":"66","year":"1985","unstructured":"DEWALD, G.W., CLINICAL CHARACTERISTICS AND PROGNOSIS OF 50 PATIENTS WITH A MYELOPROLIFERATIVE SYNDROME AND DELETION OF PART OF THE LONG ARM OF CHROMOSOME-5, BLOOD 66: 189 (1985).","journal-title":"BLOOD"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198403013100902"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6390681"},{"key":"e_1_2_1_9_1","unstructured":"Golde D. 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