{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:47:38Z","timestamp":1791190058678,"version":"4.1.0"},"reference-count":21,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4752","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1986,5,16]]},"abstract":"<jats:p>\n            Two human T-cell leukemias carrying a t(8;14)(q24;q11) chromosome translocation were studied for rearrangements and expression of the c-\n            <jats:italic>myc<\/jats:italic>\n            oncogene. For one leukemia, rearrangement was detected in a region immediately distal (3\u2032) to the c-\n            <jats:italic>myc<\/jats:italic>\n            locus; no rearrangements of c-\n            <jats:italic>myc<\/jats:italic>\n            were observed in the second case (DeF). However, studies with hybrids between human and mouse leukemic T cells indicated that in the leukemic cells of DeF, the breakpoint in chromosome 14 occurred between genes for the variable (V\n            <jats:sub>\u03b1<\/jats:sub>\n            ) and the constant (C\n            <jats:sub>\u03b1<\/jats:sub>\n            ) regions for the \u03b1 chain of the T-cell receptor. The C\n            <jats:sub>\u03b1<\/jats:sub>\n            locus had translocated to a region more than 38 kilobases 3\u2032 to the involved c-\n            <jats:italic>myc<\/jats:italic>\n            oncogene. Since human c-\n            <jats:italic>myc<\/jats:italic>\n            transcripts were expressed only in hybrids carrying the 8q+ chromosome but not in hybrids containing the normal chromosome 8, it is concluded that the translocation of the C\n            <jats:sub>\u03b1<\/jats:sub>\n            locus 3\u2032 to the c-\n            <jats:italic>myc<\/jats:italic>\n            oncogene can result in its transcriptional deregulation.\n          <\/jats:p>","DOI":"10.1126\/science.3486470","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T20:28:52Z","timestamp":1160080132000},"page":"884-886","source":"Crossref","is-referenced-by-count":153,"title":["Deregulation of c-\n            <i>myc<\/i>\n            by Translocation of the \u03b1-Locus of the T-Cell Receptor in T-Cell Leukemias"],"prefix":"10.1126","volume":"232","author":[{"given":"Jan","family":"Erikson","sequence":"first","affiliation":[{"name":"Wistar Institute, Philadelphia, PA 19104."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Finger","sequence":"additional","affiliation":[{"name":"Wistar Institute, Philadelphia, PA 19104."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Sun","sequence":"additional","affiliation":[{"name":"Wistar Institute, Philadelphia, PA 19104."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"ar-Rushdi","sequence":"additional","affiliation":[{"name":"Wistar Institute, Philadelphia, PA 19104."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuko","family":"Nishikura","sequence":"additional","affiliation":[{"name":"Wistar Institute, Philadelphia, PA 19104."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Minowada","sequence":"additional","affiliation":[{"name":"Fujisaki Cell Center, 675-1 Fujisaki, Okayama 702 Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Finan","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Laboratory Medicine and Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beverly S.","family":"Emanuel","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Laboratory Medicine and Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C.","family":"Nowell","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Laboratory Medicine and Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo M.","family":"Croce","sequence":"additional","affiliation":[{"name":"Wistar Institute, Philadelphia, PA 19104."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6414084"},{"key":"e_1_2_1_2_1","first-page":"171","volume":"300","year":"1985","unstructured":"COUBET, CJF, CR ACAD SCI B 300: 171 (1985).","journal-title":"CR ACAD SCI B"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1002\/j.1460-2075.1985.tb03921.x","volume":"4","year":"1985","unstructured":"COUBET, J.F., EMBO J 4: 2245 (1985).","journal-title":"EMBO J"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1182\/blood.V65.1.1.1","volume":"65","year":"1985","unstructured":"CROCE, C.M., MOLECULAR-BASIS OF HUMAN B-CELL NEOPLASIA, BLOOD 65: 1 (1985).","journal-title":"BLOOD"},{"key":"e_1_2_1_5_1","first-page":"6922","volume":"80","year":"1983","unstructured":"CROCE, C.M., TRANSCRIPTIONAL ACTIVATION OF AN UNREARRANGED AND UNTRANSLOCATED C-MYC ONCOGENE BY TRANSLOCATION OF A C-LAMBDA LOCUS IN BURKITT-LYMPHOMA CELLS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 80: 6922 (1983).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES"},{"key":"e_1_2_1_6_1","first-page":"3170","volume":"81","year":"1984","unstructured":"CROCE, C.M., TRANSLOCATED C-MYC ONCOGENE OF BURKITT-LYMPHOMA IS TRANSCRIBED IN PLASMA-CELLS AND REPRESSED IN LYMPHOBLASTOID-CELLS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 81: 3170 (1984).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3919442"},{"key":"e_1_2_1_8_1","first-page":"7824","volume":"79","year":"1982","unstructured":"DALLAFAVERA, R, HUMAN C-MYC ONC GENE IS LOCATED ON THE REGION OF CHROMOSOME-8 THAT IS TRANSLOCATED IN BURKITT-LYMPHOMA CELLS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 79: 7824 (1982).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1093\/nar\/13.2.381","volume":"13","year":"1985","unstructured":"EMANUEL, B.S., CHROMOSOMAL ORIENTATION OF THE LAMBDA-LIGHT CHAIN LOCUS - V-LAMBDA IS PROXIMAL TO C-LAMBDA IN 22Q11, NUCLEIC ACIDS RESEARCH 13: 381 (1985).","journal-title":"NUCLEIC ACIDS RESEARCH"},{"key":"e_1_2_1_10_1","first-page":"5611","volume":"79","year":"1982","unstructured":"ERIKSON, J, TRANSLOCATION OF IMMUNOGLOBULIN VH GENES IN BURKITT-LYMPHOMA, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 79: 5611 (1982).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED 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A., Proceedings of the National Academy of Sciences of the United States of America 83: 3439 (1986).","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"e_1_2_1_17_1","first-page":"501","volume":"5","year":"1985","unstructured":"SHOWE, L.C., CLONING AND SEQUENCING OF A C-MYC ONCOGENE IN A BURKITT-LYMPHOMA CELL-LINE THAT IS TRANSLOCATED TO A GERM LINE ALPHA-SWITCH REGION, MOLECULAR AND CELLULAR BIOLOGY 5: 501 (1985).","journal-title":"MOLECULAR AND CELLULAR BIOLOGY"},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","first-page":"4037","DOI":"10.1093\/nar\/14.10.4037","volume":"14","year":"1986","unstructured":"Sun, L. 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