{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:14:23Z","timestamp":1791137663537,"version":"4.1.0"},"reference-count":15,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4345","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1978,6,2]]},"abstract":"<jats:p>Inoculation of the buffy coat of blood from guinea pigs infected with Creutzfeldt-Jakob disease resulted in passage of this disease to recipient animals. This demonstrates that there is a viremia in experimental Creutzfeldt-Jakob disease. These findings suggest that the hematogenous route may be implicated in the human infection and that the disease may possibly be transmitted by blood transfusions.<\/jats:p>","DOI":"10.1126\/science.349691","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T16:35:25Z","timestamp":1160066125000},"page":"1069-1071","source":"Crossref","is-referenced-by-count":111,"title":["Viremia in Experimental Creutzfeldt-Jakob Disease"],"prefix":"10.1126","volume":"200","author":[{"given":"Elias E.","family":"Manuelidis","sequence":"first","affiliation":[{"name":"Departments of Pathology and Neurology, Yale University School of Medicine, New Haven, Connecticut 06510"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward J.","family":"Gorgacs","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Neurology, Yale University School of Medicine, New Haven, Connecticut 06510"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Manuelidis","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Neurology, Yale University School of Medicine, New Haven, Connecticut 06510"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","first-page":"84","volume":"6","year":"1976","unstructured":"ASHER, D.M., ANN CLIN LAB SCI 6: 84 (1976).","journal-title":"ANN CLIN LAB SCI"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1136\/vr.80.16.504","volume":"80","year":"1967","unstructured":"CLARKE, M.C., PRESENCE OF TRANSMISSIBLE AGENT OF SCRAPIE IN SERUM OF AFFECTED MICE AND RATS, VETERINARY RECORD 80: 504 (1967).","journal-title":"VETERINARY RECORD"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0021-9975(69)90021-8","volume":"79","year":"1969","unstructured":"DICKINSON, A.G., GENETICAL CONTROL OF CONCENTRATION OF ME7 SCRAPIE AGENT IN BRAIN OF MICE, JOURNAL OF COMPARATIVE PATHOLOGY 79: 15 (1969).","journal-title":"JOURNAL OF COMPARATIVE PATHOLOGY"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/infdis\/117.1.15","volume":"117","year":"1967","unstructured":"EKLUND, C.M., PATHOGENESIS OF SCRAPIE VIRUS INFECTION IN MOUSE, JOURNAL OF INFECTIOUS DISEASES 117: 15 (1967).","journal-title":"JOURNAL OF INFECTIOUS DISEASES"},{"key":"e_1_2_1_5_1","first-page":"109","volume":"83","year":"1968","unstructured":"FIELD, E.J., SCRAPIE AGENT IN BLOOD, VETERINARY RECORD 83: 109 (1968).","journal-title":"VETERINARY RECORD"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.142303"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1136\/jcp.25.Suppl_6.84","volume":"25","year":"1972","unstructured":"GIBBS, C.J., JOURNAL OF CLINICAL PATHOLOGY 25 6: 84 (1972).","journal-title":"JOURNAL OF CLINICAL PATHOLOGY"},{"key":"e_1_2_1_8_1","first-page":"195","year":"1965","unstructured":"Gibbs, C. J., Slow, Latent and Temperate Wrus Infections: 195 (1965).","journal-title":"Slow, Latent and Temperate Wrus Infections"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1093\/infdis\/129.5.559","volume":"129","year":"1974","unstructured":"HADLOW, W.J., COURSE OF EXPERIMENTAL SCRAPIE VIRUS-INFECTION IN GOAT, JOURNAL OF INFECTIOUS DISEASES 129: 559 (1974).","journal-title":"JOURNAL OF INFECTIOUS DISEASES"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.3181\/00379727-79-19398","volume":"79","year":"1952","unstructured":"HORSTMANN, D.M., POLIOMYELITIS VIRUS IN BLOOD OF ORALLY INFECTED MONKEYS AND CHIMPANZEES, PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE 79: 417 (1952).","journal-title":"PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1056\/NEJM196801042780106","volume":"278","year":"1968","unstructured":"JOHNSON, R.T., PATHOGENESIS OF VIRAL INFECTIONS OF NERVOUS SYSTEM, NEW ENGLAND JOURNAL OF MEDICINE 278: 23 (1968).","journal-title":"NEW ENGLAND JOURNAL OF MEDICINE"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1056\/NEJM196801112780205","volume":"278","year":"1968","unstructured":"JOHNSON, R.T., PATHOGENESIS OF VIRAL INFECTIONS OF NERVOUS SYSTEM (CONCLUDED), NEW ENGLAND JOURNAL OF MEDICINE 278: 84 (1968).","journal-title":"NEW ENGLAND JOURNAL OF MEDICINE"},{"key":"e_1_2_1_13_1","first-page":"223","volume":"73","year":"1976","unstructured":"MANUELIDIS, E.E., SERIAL PROPAGATION OF CREUTZFELDT-JAKOB DISEASE IN GUINEA-PIGS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 73: 223 (1976).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.190.4214.571"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0368-1742(62)80026-5","volume":"72","year":"1962","unstructured":"PATTISON, I.H., DISTRIBUTION OF SCRAPIE AGENT IN TISSUES OF EXPERIMENTALLY INOCULATED GOATS, JOURNAL OF COMPARATIVE PATHOLOGY AND THERAPEUTICS 72: 233 (1962).","journal-title":"JOURNAL OF COMPARATIVE PATHOLOGY AND THERAPEUTICS"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.349691","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T03:07:59Z","timestamp":1705201679000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.349691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,6,2]]},"references-count":15,"journal-issue":{"issue":"4345","published-print":{"date-parts":[[1978,6,2]]}},"alternative-id":["10.1126\/science.349691"],"URL":"https:\/\/doi.org\/10.1126\/science.349691","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,6,2]]}}}