{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:44:00Z","timestamp":1773290640853,"version":"3.50.1"},"reference-count":8,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6280","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2016,3,25]]},"DOI":"10.1126\/science.351.6280.1405-a","type":"journal-article","created":{"date-parts":[[2016,3,24]],"date-time":"2016-03-24T18:24:50Z","timestamp":1458843890000},"page":"1405-1405","source":"Crossref","is-referenced-by-count":27,"title":["Basic science: Bedrock of progress"],"prefix":"10.1126","volume":"351","author":[{"given":"Francis S.","family":"Collins","sequence":"first","affiliation":[{"name":"Office of the Director, NIH, Bethesda, MD 20892, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James M.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Division of Program Coordination, Planning, and Strategic Initiatives, NIH, Bethesda, MD 20892, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher P.","family":"Austin","sequence":"additional","affiliation":[{"name":"National Center for Advancing Translational Science, NIH, Rockville, MD 20850, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James F.","family":"Battey","sequence":"additional","affiliation":[{"name":"National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, MD 20892, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda S.","family":"Birnbaum","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josephine P.","family":"Briggs","sequence":"additional","affiliation":[{"name":"National Center for Complementary and Integrative Health, NIH, Bethesda, MD 20892, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janine A.","family":"Clayton","sequence":"additional","affiliation":[{"name":"Office of Research on Women's Health, NIH, Bethesda, MD 20892, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Cuthbert","sequence":"additional","affiliation":[{"name":"National Institute of Mental Health, NIH, Bethesda, MD 20892, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert W.","family":"Eisinger","sequence":"additional","affiliation":[{"name":"Office of AIDS Research, NIH, Bethesda, MD 20892, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony S.","family":"Fauci","sequence":"additional","affiliation":[{"name":"National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John I.","family":"Gallin","sequence":"additional","affiliation":[{"name":"Clinical Center, NIH, Bethesda, MD 20892, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary H.","family":"Gibbons","sequence":"additional","affiliation":[{"name":"National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger I.","family":"Glass","sequence":"additional","affiliation":[{"name":"Fogarty International Center, NIH, Bethesda, MD 20892, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael M.","family":"Gottesman","sequence":"additional","affiliation":[{"name":"Office of Intramural Research, NIH, Bethesda, MD 20892, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia A.","family":"Gray","sequence":"additional","affiliation":[{"name":"National Institute of Nursing Research, NIH, Bethesda, MD 20892, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric D.","family":"Green","sequence":"additional","affiliation":[{"name":"National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franziska B.","family":"Greider","sequence":"additional","affiliation":[{"name":"Office of Research Infrastructure Programs, NIH, Bethesda, MD 20892, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Hodes","sequence":"additional","affiliation":[{"name":"National Institute on Aging, NIH, Bethesda, MD 20892, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathy L.","family":"Hudson","sequence":"additional","affiliation":[{"name":"Office of the Director, NIH, Bethesda, MD 20892, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betsy","family":"Humphreys","sequence":"additional","affiliation":[{"name":"National Library of Medicine, NIH, Bethesda, MD 20892, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen I.","family":"Katz","sequence":"additional","affiliation":[{"name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George F.","family":"Koob","sequence":"additional","affiliation":[{"name":"National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter J.","family":"Koroshetz","sequence":"additional","affiliation":[{"name":"NINDS, NIH, Bethesda, MD 20892, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S.","family":"Lauer","sequence":"additional","affiliation":[{"name":"Office of Extramural Research, NIH, Bethesda, MD 20892, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon R.","family":"Lorsch","sequence":"additional","affiliation":[{"name":"National Institute of General Medical Sciences, NIH, Bethesda, MD 20892, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas R.","family":"Lowy","sequence":"additional","affiliation":[{"name":"National Cancer Institute, NIH, Bethesda, MD 20892, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John J.","family":"McGowan","sequence":"additional","affiliation":[{"name":"Office of Management, NIH, Bethesda, MD 20892, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Murray","sequence":"additional","affiliation":[{"name":"Office of Disease Prevention, NIH, Bethesda, MD 20892, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Center for Scientific Review, NIH, Bethesda, MD 20892, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Norris","sequence":"additional","affiliation":[{"name":"Center for Information Technology, NIH, Bethesda, MD 20892, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliseo J.","family":"Perez-Stable","sequence":"additional","affiliation":[{"name":"National Institute on Minority Health and Health Disparities, NIH, Bethesda, MD 20892, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roderic I.","family":"Pettigrew","sequence":"additional","affiliation":[{"name":"National Institute of Biomedical Imaging and Bioengineering, NIH, Bethesda, MD 20892, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William T.","family":"Riley","sequence":"additional","affiliation":[{"name":"Office of Behavioral and Social Sciences Research, NIH, Bethesda, MD 20892, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Griffin P.","family":"Rodgers","sequence":"additional","affiliation":[{"name":"National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A.","family":"Sieving","sequence":"additional","affiliation":[{"name":"National Eye Institute, NIH, Bethesda, MD 20892, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha J.","family":"Somerman","sequence":"additional","affiliation":[{"name":"National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine Y.","family":"Spong","sequence":"additional","affiliation":[{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence A.","family":"Tabak","sequence":"additional","affiliation":[{"name":"Office of the Director, NIH, Bethesda, MD 20892, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nora D.","family":"Volkow","sequence":"additional","affiliation":[{"name":"National Institute on Drug Abuse, NIH, Bethesda, MD 20892, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth L.","family":"Wilder","sequence":"additional","affiliation":[{"name":"Office of Strategic Coordination, NIH, Bethesda, MD 20892, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1227820"},{"key":"e_1_3_1_3_2","unstructured":"NIH NIH-Wide Strategic Plan (www.nih.gov\/about-nih\/nih-wide-strategic-plan)."},{"key":"e_1_3_1_4_2","unstructured":"NIH Grant Application Instructions (http:\/\/grants.nih.gov\/grants\/how-to-apply-application-guide\/forms-d\/general\/g.220-r&r-other-project-information-form.htm#8)."},{"key":"e_1_3_1_5_2","unstructured":"Landis S. Back to Basics: A call for fundamental neuroscience research (http:\/\/blog.ninds.nih.gov\/2014\/03\/27\/back-to-basics\/)."},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3513311"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1225829"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1231143"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1402809111"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.351.6280.1405-a","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T09:47:10Z","timestamp":1705225630000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.351.6280.1405-a"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,25]]},"references-count":8,"journal-issue":{"issue":"6280","published-print":{"date-parts":[[2016,3,25]]}},"alternative-id":["10.1126\/science.351.6280.1405-a"],"URL":"https:\/\/doi.org\/10.1126\/science.351.6280.1405-a","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,25]]}}}