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Both viruses were found to replicate in peripheral blood lymphocytes, but only virus from brain tissue will efficiently infect macrophage\/monocytes. The viruses also differ in their ability to infect a brain glioma explant culture. This infection of the brain-derived cells in vitro is generally nonproductive, and appears to be some form of persistent or latent infection. These results indicate that genetic variation of HIV in vivo may result in altered cell tropisms and possibly implicate strains of HIV with glial cell tropism in the pathogenesis of some neurologic disorders of AIDS.<\/jats:p>","DOI":"10.1126\/science.3646751","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T20:28:58Z","timestamp":1160080138000},"page":"819-822","source":"Crossref","is-referenced-by-count":665,"title":["Dual Infection of the Central Nervous System by AIDS Viruses with Distinct Cellular Tropisms"],"prefix":"10.1126","volume":"236","author":[{"given":"Yoshio","family":"Koyanagi","sequence":"first","affiliation":[{"name":"Division of Hematology-Oncology, Department of Medicine, UCLA School of Medicine, and Jonsson Comprehensive Cancer Center, Los Angeles, CA 90024."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Miles","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Department of Medicine, UCLA School of Medicine, and Jonsson Comprehensive Cancer Center, Los Angeles, CA 90024."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald T.","family":"Mitsuyasu","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Department of Medicine, UCLA School of Medicine, and Jonsson Comprehensive Cancer Center, Los Angeles, CA 90024."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean E.","family":"Merrill","sequence":"additional","affiliation":[{"name":"Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90024."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry V.","family":"Vinters","sequence":"additional","affiliation":[{"name":"Division of Neuropathology, Department of Pathology, UCLA School of Medicine, Los Angeles, CA 90024."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irvin S. 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