{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:00:11Z","timestamp":1790773211184,"version":"4.1.0"},"reference-count":38,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4831","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1987,11,27]]},"abstract":"<jats:p>\n            The c-\n            <jats:italic>myc<\/jats:italic>\n            proto-oncogene is involved in chromosomal translocations that are specifically and consistently found in Burkitt lymphoma. Although these translocations are thought to lead to a deregulation of c-\n            <jats:italic>myc<\/jats:italic>\n            expression, the structural and functional basis of this phenomenon has not been identified. Mutations in a specific region spanning approximately 70 base pairs and located at the 3\u2032 border of the first exon of translocated c-\n            <jats:italic>myc<\/jats:italic>\n            alleles were consistently detected in Burkitt lymphoma cells carrying classic (8:14) as well as variant (8:22 and 2:8) translocations. These structural alterations were accompanied by an altered pattern of c-\n            <jats:italic>myc<\/jats:italic>\n            transcription, namely, the removal of a block to transcriptional elongation that has been mapped to the same region. Thus, specific c-\n            <jats:italic>myc<\/jats:italic>\n            mutations leading to the alleviation of this block to transcriptional elongation may represent a general mechanism causing c-\n            <jats:italic>myc<\/jats:italic>\n            activation in Burkitt lymphoma.\n          <\/jats:p>","DOI":"10.1126\/science.3685977","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T20:28:58Z","timestamp":1160080138000},"page":"1272-1275","source":"Crossref","is-referenced-by-count":171,"title":["Mutations in the First Exon Are Associated with Altered Transcription of c-\n            <i>myc<\/i>\n            in Burkitt Lymphoma"],"prefix":"10.1126","volume":"238","author":[{"given":"Ethel","family":"Cesarman","sequence":"first","affiliation":[{"name":"Department of Pathology and Kaplan Cancer Center, New York University School of Medicine, New York, NY 10016."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Dalla-Favera","sequence":"additional","affiliation":[{"name":"Department of Pathology and Kaplan Cancer Center, New York University School of Medicine, New York, NY 10016."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Bentley","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Research Center and Department of Radiation Oncology, University of Washington School of Medicine, Seattlc, WA 98195."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Groudine","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Research Center and Department of Radiation Oncology, University of Washington School of Medicine, Seattlc, WA 98195."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/318533a0","volume":"318","year":"1985","unstructured":"ADAMS, J.M., THE C-MYC ONCOGENE DRIVEN BY IMMUNOGLOBULIN ENHANCERS INDUCES LYMPHOID MALIGNANCY IN TRANSGENIC MICE, NATURE 318: 533 (1985).","journal-title":"NATURE"},{"key":"e_1_2_1_2_1","first-page":"1982","volume":"80","year":"1983","unstructured":"ADAMS, J.M., CELLULAR MYC ONCOGENE IS ALTERED BY CHROMOSOME-TRANSLOCATION TO AN IMMUNOGLOBULIN LOCUS IN MURINE PLASMACYTOMAS AND IS REARRANGED SIMILARLY IN HUMAN BURKITT LYMPHOMAS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 80: 1982 (1983).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/0168-9525(86)90222-2","volume":"2","year":"1986","unstructured":"BARBACID, M, MUTAGENS, ONCOGENES AND CANCER, TRENDS IN GENETICS 2: 188 (1986).","journal-title":"TRENDS IN GENETICS"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/0092-8674(83)90534-2","volume":"34","year":"1983","unstructured":"BATTEY, J, THE HUMAN C-MYC-ONCOGENE - STRUCTURAL CONSEQUENCES OF TRANSLOCATION INTO THE IGH LOCUS IN BURKITT-LYMPHOMA, CELL 34: 779 (1983).","journal-title":"CELL"},{"key":"e_1_2_1_5_1","first-page":"3481","volume":"6","year":"1986","unstructured":"BENTLEY, D.L., NOVEL PROMOTER UPSTREAM OF THE HUMAN C-MYC GENE AND REGULATION OF C-MYC EXPRESSION IN B-CELL LYMPHOMAS, MOLECULAR AND CELLULAR BIOLOGY 6: 3481 (1986).","journal-title":"MOLECULAR AND CELLULAR BIOLOGY"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/321702a0","volume":"321","year":"1986","unstructured":"BENTLEY, D.L., A BLOCK TO ELONGATION IS LARGELY RESPONSIBLE FOR DECREASED TRANSCRIPTION OF C-MYC IN DIFFERENTIATED HL60 CELLS, NATURE 321: 702 (1986).","journal-title":"NATURE"},{"key":"e_1_2_1_7_1","first-page":"293","year":"1984","unstructured":"Conklin, K. 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