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The lenses of these mice displayed considerable heterogeneity: some were almost normal morphologically but reduced in size, whereas others were grossly aberrant and deficient in nuclear fiber cells. These studies indicate that programmed ablation of specific cell types can be stably transmitted through the germ line.<\/jats:p>","DOI":"10.1126\/science.3685993","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T20:28:58Z","timestamp":1160080138000},"page":"1563-1565","source":"Crossref","is-referenced-by-count":183,"title":["Genetic Ablation: Targeted Expression of a Toxin Gene Causes Microphthalmia in Transgenic Mice"],"prefix":"10.1126","volume":"238","author":[{"given":"Martin L.","family":"Breitman","sequence":"first","affiliation":[{"name":"Mount Sinai Hospital Research Institute, Toronto, Ontario, Canada M5G IX5."},{"name":"Department of Medical Genetics, University of Toronto, Toronto, Ontario, Canada M5S 1A8."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Clapoff","sequence":"additional","affiliation":[{"name":"Mount Sinai Hospital Research Institute, Toronto, Ontario, Canada M5G IX5."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Rossant","sequence":"additional","affiliation":[{"name":"Mount Sinai Hospital Research Institute, Toronto, Ontario, Canada M5G IX5."},{"name":"Department of Medical Genetics, University of Toronto, Toronto, Ontario, Canada M5S 1A8."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lap-Chee","family":"Tsui","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, University of Toronto, Toronto, Ontario, Canada M5S 1A8."},{"name":"Department of Genetics, Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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